Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies

Journal of the Neurological Sciences
Grace LeeNorman Latov

Abstract

Gene expression analysis previously identified molecular markers that are up-regulated in sural nerve biopsies from patients with chronic inflammatory demyelinating polyneuropathy (CIDP). To determine whether the same or additional genes are also up-regulated in skin, we applied gene microarray profiling and quantitative real-time PCR (qPCR) analysis to skin punch biopsies from patients with CIDP and controls. Five genes, allograft inflammatory factor 1 (AIF-1), lymphatic hyaluronan receptor (LYVE-1/XLKD1), FYN binding protein (FYB), P2RY1 (purinergic receptor P2Y, G-protein-coupled, 1), and MLLT3 (myeloid/lymphoid or mixed-lineage leukemia translocated to, 3), all associated with immune cells or inflammatory processes, were elevated in punch skin biopsies from patients with CIDP as compared to normal subjects or patients with Charcot-Marie-Tooth Type 1 (CMT1). The average fold change of the 5 genes over normal expression, as determined by qPCR, was significantly elevated in skin biopsies from patients with CIDP in comparison to CMT1 or diabetic neuropathy, and similar to that seen in Lyme disease. The findings indicate the presence of inflammatory changes in the skin of patients with CIDP.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 23, 2003·Brain : a Journal of Neurology·Chun-Liang PanSung-Tsang Hsieh
Mar 28, 2003·Muscle & Nerve·Rizwan U HaqRup Tandan
Apr 3, 2003·Immunological Reviews·Erik J Peterson
Jul 10, 2003·Lancet Neurology·Michael E ShyJohn Kamholz
Nov 11, 2003·Brain : a Journal of Neurology·Lionel GinsbergRosalind H M King
Jan 18, 2005·Journal of Neuroimmunology·Susanne RenaudNorman Latov
Jan 26, 2005·Annals of Neurology·Raffaella LombardiAndreas J Steck
Mar 19, 2005·Brain : a Journal of Neurology·Jun LiMichael E Shy
Apr 1, 2005·The New England Journal of Medicine·Hubertus KöllerHans-Peter Hartung
Oct 12, 2005·Archives of Neurology·Jing-Er LeeSung-Tsang Hsieh
Apr 25, 2007·Autoimmunity·Guangwei LiuYong Zhao
Jul 11, 2007·Archives of Neurology·Chi-Chao ChaoSong-Chou Hsieh
Mar 29, 2008·Cell Stem Cell·Cristina PinaTariq Enver
Apr 30, 2008·Immunome Research·Jane E LattinMatthew J Sweet
Sep 26, 2008·Muscle & Nerve·Laura BroglioSusanne Renaud
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Björn TackenbergJan D Lünemann
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Cristoforo ComiUmberto Dianzani

❮ Previous
Next ❯

Citations

Dec 20, 2012·Current Neurology and Neuroscience Reports·M Iliza Myers, Amanda C Peltier
Mar 25, 2014·Journal of Neuroimmunology·Stefania PuttiniThierry Kuntzer
May 7, 2013·La Presse médicale·Marinos C Dalakas
Nov 30, 2012·Muscle & Nerve·M Iliza MyersJun Li
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Claudia Sommer, Klaus Toyka
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Marinos C Dalakas
Jun 21, 2014·Biochimica Et Biophysica Acta·Marinos C Dalakas
Aug 17, 2011·Nature Reviews. Neurology·Marinos C Dalakas, UNKNOWN Medscape
Jul 1, 2011·Journal of the Peripheral Nervous System : JPNS·Norman Latov
Nov 12, 2021·Annals of Neurology·Amanda C Y ChanAnselm Mak

❮ Previous
Next ❯