Differential Gene Expression of CCK(A) and CCK(B) Receptors in the Rat Brain

Molecular and Cellular Neurosciences
T HondaS A Wank

Abstract

Cholecystokinin (CCK) is one of the most abundant peptides in the central nervous system (CNS). Radioligand-binding studies have identified and localized both central (CCK(B)-R) and peripheral (CCK(A)-R) receptor subtypes in the CNS. However, these studies have been limited by the relative specificities of agonists and antagonists for receptor subtypes and their inability to distinguish cell bodies from dendritic projection. Recently, we isolated and cloned the cDNAs for both CCK(A) and CCK(B) receptors. In the present study, (35)S-labeled cRNA antisense probes were synthesized for both receptors and in situ hybridization studies were performed in the rat brain, allowing a direct and independent comparison of the distinct distribution of expression of CCK(A) and CCK(B) receptor mRNAs in the rat brain for the first time. mRNAs for both CCK(A) and CCK(B) receptors were expressed mainly in the cortex, olfactory regions, hippocampal formation, septum, and interpeduncular nucleus. Only CCK(A) receptor mRNAs were expressed in some of the hypothalamic nuclei (paraventricular nucleus, arcuate nucleus, and medial preoptic area). In most of amygdaloid nuclei only CCK(B) receptor mRNAs were expressed. Although the presence of receptor mRN...Continue Reading

Citations

Jul 27, 2012·Chemical Senses·Brigitte Palouzier-PaulignanDebra Ann Fadool
Apr 1, 2004·Acta Neuropsychiatrica·Michel Bourin, Eric Dailly
Nov 9, 2005·The Japanese Journal of Physiology·Kyoko MiyasakaAkihiro Funakoshi
Apr 12, 2003·Pharmacology & Toxicology·Tomas HökfeltSen Ove Ogren
Apr 12, 2003·Pharmacology & Toxicology·Paul MicevychKevin Sinchak
Jul 16, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Yuchuan ZhouYonglian Zhang
Jul 1, 2014·The Journal of Comparative Neurology·Gregory S ParksOlivier Civelli
Jan 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Spencer P Loewen, Alastair V Ferguson
Jun 5, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shigeki NomotoKyoko Miyasaka
Dec 1, 2006·The Journal of Physiological Sciences : JPS·Chihiro SakuraiKyoko Miyasaka
Mar 16, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Kyoko MiyasakaAkihiro Funakoshi
Jan 1, 1999·Amino Acids·C BrobergerT Hökfelt
May 14, 2008·Neurochemical Research·Miguel Pérez de la MoraKjell Fuxe
Jan 1, 1996·Fundamental & Clinical Pharmacology·M BourinJ Bradwejn
Dec 15, 2010·Developmental Neurobiology·Soo Yeun Lee, Ivan Soltesz
Jul 1, 1996·Japanese Journal of Cancer Research : Gann·T MurayamaT Matsui
Mar 22, 2012·British Journal of Pharmacology·Amanda J PageRichard L Young
Mar 31, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Go YoshimichiPatrick Tso
May 4, 2012·Depression and Anxiety·P ZwanzgerJ Bradwejn
Jul 5, 2019·Annals of the New York Academy of Sciences·Lucas B ComerasRamon O Tasan
Oct 6, 2012·The Journal of Biological Chemistry·Shahid MohammadMasayuki Ikeda
Mar 28, 2017·Reviews in the Neurosciences·Santiago Ballaz
Feb 28, 2013·American Journal of Physiology. Endocrinology and Metabolism·Ian C DunnPaul M Hocking
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert C Ritter
Dec 20, 2019·Clinical Medicine Insights. Endocrinology and Diabetes·Jens F Rehfeld
Apr 30, 2017·Frontiers in Endocrinology·Jens F Rehfeld
Mar 27, 2020·Frontiers in Endocrinology·Qiang ZengDong-Yu Guo
Nov 2, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James E BlevinsKozo Matsumoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.