Differential gene expression profile of MAGE family in taiwanese patients with colorectal cancer

Journal of Surgical Oncology
Fu-Yen ChungShiu-Ru Lin

Abstract

The melanoma-associated antigen (MAGE) gene family consists of different expression patterns in various tumor types. They are considered tumor-specific antigens and are ideal targets for cancer immunotherapy. The purpose of this study is to identify the expression profiles of the MAGE family genes in Taiwanese colorectal cancer patients. In this study, a well-constructed chip array platform was used to analyze the expression of the MAGE family genes of 100 colorectal cancer tissues. Statistical analysis of the experimental results and patients' clinical manifestations were also conducted. The results showed MAGE-A2 (87%), -A7 (83%), -A8 (75%), -A12 (71%), -B2 (75%), -B3 (79%), -D2 (75%), -F1 (79%), and -H1 (70%) were significantly overexpressed genes in colorectal cancer tissues. MAGE-A2 was the most highly overexpressed gene among the MAGE family. MAGE-B3 gene expression is statistically correlated with tumor size, lymph node, and UICC stage. In addition, the overexpression of MAGE-D2 and -H1 genes are statistically correlated to the tumor size and depth, respectively (P < 0.05). This is the first comprehensive report to clarify the differential expression profile of whole MAGE family in CRCs, and it might provide some crucial...Continue Reading

References

Nov 15, 1996·International Journal of Cancer. Journal International Du Cancer·A SerranoF Ruiz-Cabello
Apr 7, 2000·Breast Cancer Research and Treatment·R A KurtD D Schoof
Nov 5, 2002·The Journal of Biological Chemistry·Marianna TcherpakovMike Fainzilber
Jun 29, 2004·World Journal of Gastroenterology : WJG·Jiang Xiao, Hong-Song Chen
Jul 19, 2005·Cancer Immunology, Immunotherapy : CII·Sabrina OttavianiPierre van der Bruggen
Oct 18, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shinya ItoFumihiro Tanaka
May 12, 2006·Molecular Cancer Research : MCR·Frank WischnewskiHeidi Schwarzenbach
Sep 9, 2006·Cancer Immunology, Immunotherapy : CII·Pedro M S AlvesFrédéric Lévy
Jul 22, 2009·BMC Cancer·Fu-Yen ChungShiu-Ru Lin

❮ Previous
Next ❯

Citations

Sep 1, 2012·Journal of Translational Medicine·Zhao-lei ZengRui-hua Xu
Dec 27, 2015·Biochimica Et Biophysica Acta·Céline PirlotYvette Habraken
May 27, 2011·Annals of Medicine·Xiaohan WangYing Xu
Nov 16, 2016·Disease Markers·Qian ZhaoTuluhong Shalieer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jaw-Yuan WangYih-Huei Uen
Proceedings of the National Academy of Sciences of the United States of America
E RacilaJ W Uhr
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Graeme J PostonMichael I D'Angelica
© 2021 Meta ULC. All rights reserved