Differential gene expression profiling of the sciatic nerve in type 1 and type 2 diabetic mice

Biomedical Reports
Yu GuXiang Li

Abstract

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The pathogenic mechanisms of DPN and the therapeutic interventions required may be distinct between type 1 (T1) and type 2 (T2) DM. However, the molecular mechanisms underlying the pathogenesis of DPN in both types of diabetes remain unclear. The aim of the current study was to identify the changes in genes and pathways associated with DPN in sciatic nerves of T1- and T2DM mice using bioinformatics analysis. The microarray profiles of sciatic nerves of T1DM (GSE11343) and T2DM (GSE27382) mouse models were downloaded from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) in each. DEGs in the two types of DM (with fold change ≥2 and P<0.05) were identified with BRB-ArrayTools. Gene Ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery. A protein-protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins and visualized using Cytoscape. Compared with control samples, 623 and 1,890 DEGs were identified in sciatic nerve...Continue Reading

References

Nov 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·W RathmannF A Gries
May 6, 2004·American Journal of Physiology. Endocrinology and Metabolism·Martin J StevensAnders A F Sima
Mar 5, 2005·Diabetes/metabolism Research and Reviews·Hideki KamiyaAnders A F Sima
May 30, 2006·Anesthesiology·Michael L Lacroix-FralishJoyce A DeLeo
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Catherine Mounier, Barry I Posner
Dec 8, 2006·Annals of the New York Academy of Sciences·Anders A F Sima, Hideki Kamiya
Sep 9, 2008·Reviews in Endocrine & Metabolic Disorders·K J Chang-ChenE Bernal-Mizrachi
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Mar 30, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kenji Matsumoto, Shin-ichiro Yokoyama
Aug 4, 2011·Endocrinology·Bhumsoo KimEva L Feldman
Sep 14, 2011·Nature Reviews. Neurology·Andrea M VincentEva L Feldman
Feb 1, 2012·Diabetes/metabolism Research and Reviews·Solomon Tesfaye, Dinesh Selvarajah
Aug 16, 2012·Current Opinion in Neurology·Brian C CallaghanEva L Feldman
Jun 1, 2013·Cell Biochemistry and Biophysics·Louis S Premkumar, Reddy M Pabbidi
Mar 13, 2014·ILAR Journal·Phillipe D O'BrienEva L Feldman
Dec 2, 2014·International Journal of Molecular Medicine·Lei ZhangHao Wang
Apr 29, 2015·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·W QuL Li
Dec 31, 2016·Neurological Research·Jing WangYing-Hai Jiang
Feb 6, 2017·Experimental & Molecular Medicine·Luong Dai LyKyu-Sang Park

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE11343
GSE27382
GSM286178
GSM286430
GSM286163
GSM286165

Software Mentioned

Cytoscape
ClusterONE
ArrayTools
BRB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.