Nov 1, 1996

Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Norman J WilsmanC Barreto

Abstract

Differential elongation of growth plates is the process by which growth-plate chondrocytes translate the same sequence of gene regulation into the appropriate timing pattern for a given rate of elongation. While some of the parameters associated with differential growth are known, the purpose of this study was to test the hypothesis that eight independent variables are involved. We tested this hypothesis by considering four different growth plates in 28-day-old Long-Evans rats. Temporal parameters were provided by means of oxytetracycline and bromodeoxyuridine labeling techniques. Stereological parameters were measured with standard techniques. For all four growth plates, the calculated number of new chondrocytes produced per day approximated the number of chondrocytes lost per day at the chondro-osseous junction. This suggests that the proposed equations and associated variables represent a comprehensive set of variables defining differential growth. In absolute numbers, the proximal tibial growth plate produced about four times as many chondrocytes per day as the proximal radial growth plate (16,400 compared with 3,700). In the proximal tibia, 9% of growth is contributed by cellular division; 32%, by matrix synthesis througho...Continue Reading

  • References21
  • Citations135

Citations

Mentioned in this Paper

Developmental Growth Involved in Morphogenesis
August Rats
Oxytetracycline
Hypertrophy
Chondrocyte
Epiphysis of Bone
Bone Tissue
Bone Matrix
Cell Cycle
Bone Structure of Tibia

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