PMID: 9189825Jun 15, 1997Paper

Differential healing and neovascularization of ePTFE implants in subcutaneous versus adipose tissue

Journal of Biomedical Materials Research
S K WilliamsLeigh B Kleinert

Abstract

The preclinical evaluation of polymer biocompatibility is often performed using animal subcutaneous implant models. The choice of subcutaneous tissue as the implant site is due to a number of factors including simplicity of the surgery involved. Results from subcutaneous implants cannot necessarily be extrapolated to other tissues due to the differences in cellular composition of tissues. We have evaluated and compared the healing characteristics of expanded polytetrafluoroethylene (ePTFE) discs implanted in either subcutaneous tissue or epididymal fat pad tissue in rats. Following 3 and 5 weeks of implantation, the healing characteristics of discs were evaluated histologically with particular emphasis on tissue and polymer neovascularization. Implants placed in subcutaneous tissue exhibited limited formation of new microvascular elements within and directly in contact with the polymer, and the formation of an extensive fibrous capsule. In contrast, ePTFE implanted in the epididymal fat pads of rats exhibited extensive neovascularization of tissue surrounding the polymer, penetration of these microvascular cells into the graft interstices for distances < or = 100 microns and no morphological evidence of a fibrous capsule. The r...Continue Reading

References

Jan 1, 1991·Ophthalmic Plastic and Reconstructive Surgery·J W KareshM M Rodrigues
Feb 1, 1991·The Annals of Thoracic Surgery·J P ChristyS A Thompson
Jul 1, 1989·The Journal of Surgical Research·C MechemS K Williams
Nov 1, 1982·Journal of Biomedical Materials Research·P Beahan, D Hull
May 1, 1994·Microvascular Research·F M Hansen-SmithJ L Baustert
Feb 1, 1994·Journal of Biomedical Materials Research·V Trinkaus-RandallC Franzblau

❮ Previous
Next ❯

Citations

Oct 5, 2007·Journal of Materials Science. Materials in Medicine·Yu Mi LeeHyun Wook Cho
Oct 12, 2000·Biomaterials·A L Sieminski, K J Gooch
Mar 21, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·D L SalzmannS K Williams
May 18, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·C J ArpeyD C Whitaker
Nov 1, 2006·Biomaterials·Heather L PrichardBruce Klitzman
May 10, 2008·Journal of Biomedical Materials Research. Part a·Philip V PeplowRobert J Kelly
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·Errol WijelathMichael Sobel
Aug 25, 2010·Journal of Biomedical Materials Research. Part a·Gabriel GruionuStuart K Williams
Apr 6, 2004·Facial Plastic Surgery Clinics of North America·Craig D Friedman
Apr 26, 2008·Stem Cells·Heather L PrichardBruce Klitzman
Jul 2, 2009·Journal of Biomedical Materials Research. Part a·Qiang WangRichard T Schoephoerster
Jul 9, 1999·Journal of Biomedical Materials Research·A RosengrenL M Bjursten
Oct 6, 2010·Journal of Diabetes Science and Technology·Heather L PrichardBruce Klitzman
May 15, 2002·Journal of Biomedical Materials Research·Robert S KellarStuart K Williams
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Agneta Rosengren, Lars Magnus Bjursten
Apr 2, 2004·Journal of Biomedical Materials Research. Part a·Kameha R Kidd, Stuart K Williams
Sep 15, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T A M AndradeM A C Frade
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·N WisniewskiU Ungerstedt
Jan 5, 2002·Journal of Biomedical Materials Research·Kameha R KiddStuart K Williams
Apr 8, 2006·Journal of Biomedical Materials Research. Part a·Stuart K WilliamsDavid L Clapper
Jul 11, 1998·Journal of Biomedical Materials Research·D L SalzmannS K Williams
Feb 20, 2016·Journal of Developmental Biology·Jean-Christophe TilleBeat H Walpoth
Oct 28, 2004·Journal of Biomedical Materials Research. Part a·Rebecca S ShawgoMichael J Cima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.