Differential hormonal regulation of estrogen receptors ERalpha and ERbeta and androgen receptor expression in rat efferent ductules

Reproduction : the Official Journal of the Society for the Study of Fertility
Cleida A OliveiraR A Hess

Abstract

Estrogen receptors, in addition to the androgen receptor (AR), are expressed at high levels in efferent ductules of the male reproductive tract and it is now well recognized that estrogen receptor (ER) alpha is required for the maintenance of normal structure and function of the ductules. However, little is known regarding the hormonal regulation of the receptors themselves in the male. In the present study, efferent ductule ligation and castration, followed by replacement with testosterone, dihydro-testosterone (DHT) or estradiol was used to investigate the relative importance of circulating and luminal sources of steroid for the modulation of ERalpha, ERbeta and AR in rat efferent ductules. Uni- or bilateral castration and ligation did not affect the expression of ERalpha and ERbeta, but bilateral castration caused down-regulation of AR. Replacement with DHT and testosterone alone or in combination with estradiol caused the recovery of AR expression to control levels. A slight recovery of AR was also observed after estrogen replacement. ERalpha expression was decreased to nearly undetectable levels after estrogen replacement. On the other hand, ERbeta did not show evident effects following any of the treatments, suggesting a ...Continue Reading

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Citations

Oct 12, 2010·Biology of Reproduction·Avenel JosephRex A Hess
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serge Carreau, Rex A Hess
Oct 10, 2006·Reproductive Biology and Endocrinology : RB&E·Patrícia Picciarelli-LimaCleida A Oliveira
Apr 19, 2012·Experimental & Molecular Medicine·Siriporn Chamniansawat, Sukumal Chongthammakun
Jul 20, 2012·General and Comparative Endocrinology·Renee ZayaChristopher A Pearl
Feb 27, 2007·Domestic Animal Endocrinology·Christopher A Pearl, Janet F Roser
Dec 13, 2006·General and Comparative Endocrinology·Rubem A P DornasCleida A Oliveira
Dec 4, 2008·The Journal of Comparative Neurology·Di WuAndrea C Gore
Jan 12, 2007·Reproduction in Domestic Animals = Zuchthygiene·C KohlerB Hoffmann
Jan 4, 2012·Reproduction in Domestic Animals = Zuchthygiene·A GunawanK Schellander
Oct 13, 2006·Domestic Animal Endocrinology·Christopher A PearlJanet F Roser
Dec 2, 2010·General and Comparative Endocrinology·André G OliveiraCleida A Oliveira
Sep 10, 2010·Biology of Reproduction·Gisele Renata Oliveira GomesCatarina Segreti Porto
Jun 18, 2010·Biology of Reproduction·Jessica D SherrillBenson T Akingbemi
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Maria Fatima Magalhães LazariCatarina Segreti Porto
Feb 14, 2018·Biology of Reproduction·Rex A Hess, Paul S Cooke
May 26, 2017·Physiological Reviews·Paul S CookeRex A Hess
Jun 10, 2005·Reproduction in Domestic Animals = Zuchthygiene·H M MutembeiB Hoffmann
Jun 25, 2017·Endocrinology·Guangxin YaoYonglian Zhang
Jul 4, 2019·Journal of Neuroendocrinology·Noelia P Di GiorgioVictoria Lux-Lantos
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jorge M NaciffGeorge P Daston
Apr 20, 2018·Nature Reviews. Urology·Shoko MatsushitaGen Yamada
Jun 6, 2018·Frontiers in Endocrinology·Zulvikar Syambani Ulhaq, Mitsuyo Kishida
May 13, 2020·International Journal of Molecular Sciences·Cristina V DieniRoberto Panichi
Jan 15, 2021·Differentiation; Research in Biological Diversity·Rex A HessBarry T Hinton
Aug 18, 2020·Molecular and Cellular Endocrinology·Ladan MarboutiMahdi Shafiee Sabet

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