Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia

Microbiome
Bruce A RosaMakedonka Mitreva

Abstract

The human intestine and its microbiota is the most common infection site for soil-transmitted helminths (STHs), which affect the well-being of ~ 1.5 billion people worldwide. The complex cross-kingdom interactions are not well understood. A cross-sectional analysis identified conserved microbial signatures positively or negatively associated with STH infections across Liberia and Indonesia, and longitudinal samples analysis from a double-blind randomized trial showed that the gut microbiota responds to deworming but does not transition closer to the uninfected state. The microbiomes of individuals able to self-clear the infection had more alike microbiome assemblages compared to individuals who remained infected. One bacterial taxon (Lachnospiracae) was negatively associated with infection in both countries, and 12 bacterial taxa were significantly associated with STH infection in both countries, including Olsenella (associated with reduced gut inflammation), which also significantly reduced in abundance following clearance of infection. Microbial community gene abundances were also affected by deworming. Functional categories identified as associated with STH infection included arachidonic acid metabolism; arachidonic acid is ...Continue Reading

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Citations

Aug 10, 2018·PLoS Neglected Tropical Diseases·Ivonne MartinMaria Yazdanbakhsh
Nov 16, 2019·PLoS Pathogens·Maya GloverRichard K Grencis
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Mar 30, 2021·Frontiers in Cellular and Infection Microbiology·Bruce A RosaMakedonka Mitreva
May 4, 2021·Frontiers in Microbiology·Dawit WoldayTobias F Rinke de Wit

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Datasets Mentioned

BETA
PRJNA407815

Methods Mentioned

BETA
PCR
MDA
RNA-Seq

Software Mentioned

SPARCC
Mothur
Burrows
MBLASTX
Cytoscape
PICRUSt
HUMAnN
DESeq2
TrimBWAStyle
bedtools

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