Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study

Annals of the Rheumatic Diseases
Lihi EderD D Gladman

Abstract

A recent population-based study identified several HLA alleles as conferring a risk for psoriatic arthritis (PsA) among patients with psoriasis. The authors aimed to confirm these results using a family-based association study. PsA probands, psoriasis probands and their first-degree family members were included. All participants were evaluated for the presence of psoriasis and inflammatory arthritis. HLA-B and -C genotyping was performed. The family-based association test was used to test for differences between PsA and psoriasis patients in transmission of candidate alleles from parents to offspring. A total of 178 PsA and 30 psoriasis probands and 561 first degree family members were analysed. The following HLA alleles were over-transmitted to PsA compared with psoriasis: HLA-C*12 (p=0.005), HLA-B*38 (p=0.04), HLA-B*39 (p=0.03), HLA-B*27 (p=0.002). HLA-B*27, HLA-B*38, HLA-B*39 and HLA-C*12 alleles are potential PsA-specific genetic markers among patients with psoriasis.

Citations

Feb 12, 2014·Current Rheumatology Reports·Anand N MalaviyaUma Kanga
Aug 21, 2015·Rheumatology·Rubén QueiroBelén Acasuso
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Darren D O'Rielly, Proton Rahman
Aug 7, 2013·Human Immunology·Vinod ChandranDafna D Gladman
Jul 19, 2014·Biomarkers in Medicine·Constantin CaruntuMonica Neagu
Aug 5, 2014·American Journal of Human Genetics·Yukinori OkadaSoumya Raychaudhuri
Jan 30, 2016·Expert Review of Clinical Immunology·Elena GeneraliCarlo Selmi
Oct 21, 2016·Expert Review of Clinical Immunology·Salvatore D'AngeloIgnazio Olivieri
Nov 22, 2014·Current Opinion in Rheumatology·Lihi EderDafna D Gladman
Nov 30, 2019·ACR Open Rheumatology·Ruby J SiegelSalahuddin Ahmed
Nov 20, 2019·Biostatistics·Jooyoung Lee, Richard J Cook
Mar 4, 2019·Archives of Dermatological Research·Jingjing ChenXuejun Zhang
May 23, 2021·Best Practice & Research. Clinical Rheumatology·Darren D O'Rielly, Proton Rahman

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