Differential immune response of vitellogenin gene to Vibrio anguillarum in noble scallop Chlamys nobilis and its correlation with total carotenoid content

Fish & Shellfish Immunology
Qian ZhangShengkang Li

Abstract

Vitellogenin (Vg), an egg yolk precursor protein, not only functions as a source of nutrients and a nonpolar molecular carrier that combine and transfer lipids, proteins, vitamin and carotenoids to oocytes during the oogenesis. but also links with the immune defense in many oviparous animals. To investigate whether Vg plays a immune defensive role in noble scallop Chlamys nobilis, an acute Vibrio anguillarum infection experiment was conducted in orange and brown scallops with different carotenoids content. qRT-PCR result showed that Vg transcripts were significantly up-regulated after challenge with V. anguillarum in orange and brown shell scallops compared to the control group and Vg expression reached the highest spot at 6 h, indicated that Vg possessed an immune function in the noble scallop. Interestingly, a significantly positive correlation between Vg transcript levels and total carotenoids content in the ovary was observed, indicating that Vg gene expression was up regulated by carotenoids. The results suggest that Vg is a potent immune protector and carotenoid may linked with Vg plays an important role in host immune system against pathogens in noble scallop C. nobilis.

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Citations

Jul 28, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Ya'nan YangHaihui Ye
Oct 18, 2019·Frontiers in Physiology·Yan ShenChuan-Xi Zhang
Feb 6, 2020·Frontiers in Immunology·Karsoon TanHuaiping Zheng
May 6, 2020·Environmental Science and Pollution Research International·Jacopo FabrelloValerio Matozzo

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