Differential Immune Responses to New World and Old World Mammalian Arenaviruses

International Journal of Molecular Sciences
Hinh Ly

Abstract

Some New World (NW) and Old World (OW) mammalian arenaviruses are emerging, zoonotic viruses that can cause lethal hemorrhagic fever (HF) infections in humans. While these are closely related RNA viruses, the infected hosts appear to mount different types of immune responses against them. Lassa virus (LASV) infection, for example, results in suppressed immune function in progressive disease stage, whereas patients infected with Junín virus (JUNV) develop overt pro-inflammatory cytokine production. These viruses have also evolved different molecular strategies to evade host immune recognition and activation. This paper summarizes current progress in understanding the differential immune responses to pathogenic arenaviruses and how the information can be exploited toward the development of vaccines against them.

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Citations

Jan 27, 2019·Vaccines·Federico Perdomo-CelisJuan C Zapata
Feb 2, 2018·International Journal of Molecular Sciences·Susanna K P Lau
Mar 29, 2019·Frontiers in Immunology·Morgan E Brisse, Hinh Ly
Feb 13, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Mara Lucia GravinattiFábio Gregori
Nov 27, 2020·Cells·Jorlan FernandesAlexandro Guterres

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Methods Mentioned

BETA
nuclear translocation

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Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.