Differential impact of antiepileptic drugs on the effects of contraceptive methods on seizures: Interim findings of the epilepsy birth control registry

Seizure : the Journal of the British Epilepsy Association
Andrew G Herzog

Abstract

To present the interim findings of the Epilepsy Birth Control Registry (EBCR) regarding the impact of various contraceptive methods on seizures, stratified by antiepileptic drug (AED) type. This is an observational study that reports interim findings on the first 750 subjects. There are significantly greater relative risks (RR) for both seizure increase and decrease with hormonal contraception (HC) than with non-hormonal contraception (NHC). The rates of HC experiences associated with seizure increase (21.0%) are greater than with NHC (3.9%) (RR=5.39 [95% CI=3.77-7.73, p<0.0001]). The rates of HC experiences associated with seizure decrease (10.3%) are greater than with NHC (5.6%) (RR=1.85 [95% CI=1.30-2.62, p=0.0006]). While differences can reflect biological effects or reporting bias, the finding of a greater RR for seizure increase with hormonal patch than with combined oral contraceptive, perhaps related to the delivery of substantially higher concentrations of hormones, and a greater RR for seizure decrease with depomedroxyprogesterone, known to reduce seizure frequency when used in dosages which produce amenorrhea, support biological effects. All AED categories showed significantly higher frequencies of reports of seizure...Continue Reading

References

Jun 1, 1990·Archives of Neurology·J I IsojärviV V Myllylä
Dec 5, 2003·Epilepsy & Behavior : E&B·Andres M Kanner
Dec 28, 2006·Neurology·Cynthia L Harden, Ilo Leppik
Jan 1, 2008·Seizure : the Journal of the British Epilepsy Association·Andrew G Herzog
Jan 22, 2008·Seizure : the Journal of the British Epilepsy Association·Anne Sabers

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Citations

Feb 14, 2016·Epilepsy Research·Iyan Younus, Doodipala Samba Reddy
Nov 10, 2016·Epilepsy & Behavior : E&B·Alyssa R EspineraElizabeth E Gerard
Oct 4, 2016·Expert Review of Neurotherapeutics·Doodipala Samba Reddy
Mar 29, 2019·Continuum : Lifelong Learning in Neurology·Mona Sazgar
Oct 5, 2018·Neurology·Anup D PatelS Andrew Josephson
Jun 19, 2019·Epilepsy Currents·Naymee Velez-Ruiz
Sep 11, 2018·Seizure : the Journal of the British Epilepsy Association·Barbara MostacciPaolo Tinuper

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