Differential impact of cocaine on meal patterns in female and male rats.

Life Sciences
Paul WellmanJack Nation

Abstract

Female rats, relative to males, exhibit greater behavioral activation to cocaine and other psychostimulants, but the effect of sex and the estrous cycle in modulating the hypophagic action of cocaine has not been evaluated. Meal patterns were recorded in automated food hoppers during the first 3 h of the dark phase in adult female and male rats after administration of ascending cocaine doses (0, 7.5, and 15 mg/kg cocaine, i.p.) on successive trials. Cocaine produced a greater suppression of feeding as well as a reduction in meal number over a 3 h test period in female rats during estrus, relative to that noted during diestrus. In contrast, during the 180 min test period, male rats showed minimal hypophagic responses to 7.5 or 15 mg/kg cocaine. These results extend the range of behavioral perturbations induced by cocaine that are modulated by sex and by the estrous cycle and are consistent with the notion that estradiol may modulate the neurochemical actions of cocaine.

References

Jun 28, 1979·Psychopharmacology·D C BalopoleD Dorph
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·C W BertholdJ M Moerschbaecher
Jan 1, 1986·Psychopharmacology·R E Tessel, J E Barrett
Jun 1, 1987·Life Sciences·M E Carroll, S T Lac
Mar 1, 1982·Neurochemical Research·N Blavet, F V DeFeudis
Feb 1, 1994·The Journal of Pharmacy and Pharmacology·Y K Fung, L A Richard
May 9, 1998·Addictive Behaviors·C CochraneT Brewerton
Jan 25, 2000·Neuroendocrinology·A J Justice, H de Wit
Apr 21, 2001·Psychopharmacology·M E LiechtiF X Vollenweider
Aug 31, 2001·JAMA : the Journal of the American Medical Association·H M BlanckM K Serdula
Jul 12, 2003·Obesity Research·Constance FarleyTimothy J Kowalski
Sep 16, 2003·Drugs of Today·Christian P MüllerJoseph P Huston
Dec 25, 2004·Endocrinology·Jill B BeckerElizabeth Young
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lisa A EckelDeann P D Atchley
Sep 6, 2005·Physiology & Behavior·Heidi M Rivera, Lisa A Eckel
Dec 17, 2005·Pharmacology, Biochemistry, and Behavior·Paul J WellmanKristina W Davis
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lori Asarian, Nori Geary
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson

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