Dec 17, 2016

Differential Impacts of Alternative Splicing Networks on Apoptosis

International Journal of Molecular Sciences
Jung-Chun LinYing-Ju Lin


Apoptosis functions as a common mechanism to eliminate unnecessary or damaged cells during cell renewal and tissue development in multicellular organisms. More than 200 proteins constitute complex networks involved in apoptotic regulation. Imbalanced expressions of apoptosis-related factors frequently lead to malignant diseases. The biological functions of several apoptotic factors are manipulated through alternative splicing mechanisms which expand gene diversity by generating discrete variants from one messenger RNA precursor. It is widely observed that alternatively-spliced variants encoded from apoptosis-related genes exhibit differential effects on apoptotic regulation. Alternative splicing events are meticulously regulated by the interplay between trans-splicing factors and cis-responsive elements surrounding the regulated exons. The major focus of this review is to highlight recent studies that illustrate the influences of alternative splicing networks on apoptotic regulation which participates in diverse cellular processes and diseases.

  • References131
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Nested Transcripts
Cellular Process
Apoptosis, Intrinsic Pathway
RNA Precursor
Self Renewing Cell
Malignant Paraganglionic Neoplasm

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Molecular Cell
Christian Schwerk, Klaus Schulze-Osthoff
Journal of Cell Science
Anabella Srebrow, Alberto R Kornblihtt
Molecular and Cellular Biochemistry
Mohammad Shamsul OlaHaseeb Ahsan
© 2020 Meta ULC. All rights reserved