Differential impacts of cardiac and abdominal ectopic fat deposits on cardiometabolic risk stratification

BMC Cardiovascular Disorders
Fu-Zong WuMing-Ting Wu

Abstract

Previous studies have shown that excessive abdominal visceral adipose tissue (AVAT) and epicardial adipose tissue (EAT) are risk factors of cardiometabolic disease; we hypothesized there is differential contribution of abdominal and cardiac fat deposits to the cardiometabolic profiles. Two hundred eight consecutive subjects with clinical suspicion of coronary artery disease (CAD) who underwent cardiac and abdominal CT for Agatston score and abdominal visceral fat measurement were retrospectively analyzed. Regional thickness of EAT (EATth), total volume of EAT, total volume of paracardial adipose tissue (PAT) and total volume of AVAT from L2 to L5 level were measured. The relationships between abdominal and cardiac adipose tissue measurements, the number of components of metabolic syndrome, and the severity of Agatston score on a four ranking scale (0, 1-10,11-100, 101-400, >400) were investigated. The amounts of AVAT, EAT, PAT and EATth-LAVG showed a significant linear trend with increasing number (0-5) of components in metabolic syndrome (AVAT, EAT and PAT P for trend <0.0001; EATth-LVAG P for trend <0.001). EATth at left atrioventricular groove (EATth-LAVG) showed significant linear trend with the severity of Agatston score o...Continue Reading

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Citations

Mar 17, 2018·Hormone Molecular Biology and Clinical Investigation·Kai G KahlUlrich Schweiger
Apr 24, 2018·European Journal of Clinical Investigation·Chia-Yu WangChing-Yi Chen
Oct 10, 2019·Archives of Physiology and Biochemistry·Maxim Yu SinitskyAnastasia V Ponasenko
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Apr 19, 2017·Obesity Research & Clinical Practice·Chandramouli KrishnanMark D Peterson

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