PMID: 8950455Nov 1, 1996Paper

Differential in vitro responses of elastin expression to basic fibroblast growth factor and transforming growth factor beta 1 in upper, middle and lower dermal fibroblasts

Archives of Dermatological Research
S Tajima, T Izumi

Abstract

Elastin mRNA levels were measured in cultured skin fibroblasts derived from upper, middle and lower dermal layers. The elastin mRNA levels were highest in the fibroblasts from the upper dermal layer and lowest in the lower dermal fibroblasts. Modulation of elastin expression by basic fibroblast growth factor and transforming growth factor beta 1 in the dermal fibroblasts was also studied. Basic fibroblasts growth factor downregulated elasin expression in the upper dermal fibroblasts but did not significantly change elastin expression in the middle and lower dermal fibroblasts. Upregulation of elastin expression by transforming growth factor beta 1 was greater in the upper dermal fibroblasts than in the middle and lower dermal fibroblasts. Platelet-derived growth factor induced no significant changes in the three types of dermal fibroblasts. The results suggest that the differential responses of elastin expression to potent modulators may be at least partially responsible for the abnormal elastin metabolism specifically observed in the upper dermal layer.

References

Mar 1, 1977·Cell Biology International Reports·G L GroveV J Cristofalo
Apr 1, 1992·Journal of the American Academy of Dermatology·F Rongioletti, A Rebora
Apr 30, 1990·Biochemical and Biophysical Research Communications·T IchiroT Nishikawa
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Z IndikJ Rosenbloom
Aug 15, 1988·Biochemical and Biophysical Research Communications·J M Liu, J M Davidson
Feb 20, 1986·The New England Journal of Medicine·R Ross
Mar 12, 1971·Science·R FleischmajerA Nedwich
Feb 1, 1982·Arthritis and Rheumatism·G R BotsteinE C Leroy
May 1, 1981·The Journal of Investigative Dermatology·R FleischmajerR Timpl

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Citations

Nov 10, 2006·Cell and Tissue Research·J Michael SorrellArnold I Caplan
Jan 29, 2000·The Journal of Investigative Dermatology·F Duplan-PerratF Braye
Apr 10, 2015·Journal of Biomedical Materials Research. Part a·Omolbanin MirdailamiFatemeh Atyabi
Jul 9, 2009·International Review of Cell and Molecular Biology·J Michael Sorrell, Arnold I Caplan
Jan 3, 2013·Experimental Dermatology·David JansonAbdoelwaheb El Ghalbzouri
Apr 4, 2021·International Journal of Molecular Sciences·Bashair M MussaSallam Hasan Abdallah

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