Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic aromatic hydrocarbons

Archives of Toxicology
Peter H Roos

Abstract

We have analyzed the induction of the cytochrome P450 enzyme CYP1A1 as a biomarker of effect in duodenum, liver and kidney of rats after oral intake of contaminated soil particles. The soil samples originated from industrial sites and were contaminated with polycyclic aromatic hydrocarbons (PAH) to variable extents, ranging from 60 to 4700 mg PAH/kg soil. Soil samples were administered for one week as a mixture with commercial rodent diets. After exposure, microsomes of several organs were prepared and analyzed for CYP1A1, enzymatically and by Western blots. All contaminated soils led to induction of CYP1A1 in duodenal mucosa cells, regardless of their extent of contamination, showing that relevant doses were mobilized in the gastrointestinal tract and adsorbed. Subsequent distribution of non-metabolized compounds is indicated by induction of CYP1A1 in the liver. However, some samples did not lead to a response in the liver, due to their quantitative and qualitative contaminant composition. In accordance with previous results, there is a sigmoidal dose-response relationship between induction of hepatic CYP1A1 levels and the soil contamination with higher condensates of PAH. In contrast, the response in the duodenum appeared to ...Continue Reading

Citations

Sep 18, 2007·Archives of Toxicology·Sylvie ChatyPaule Vasseur
Jul 19, 2008·Archives of Toxicology·Sabine PlöttnerWolfram Föllmann
Nov 8, 2008·Archives of Toxicology·Alexandra BorzaWolfram Föllmann
Jan 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jane A ManteyAramandla Ramesh
Sep 22, 2012·Journal of Toxicology and Environmental Health. Part a·Sabine PlöttnerWolfram Föllmann
Aug 9, 2003·International Journal of Food Sciences and Nutrition·Nanna RoosShakuntala Haraksingh Thilsted
Jan 30, 2016·Environmental Science & Technology·Michael V RubyCharles A Menzie
Jan 6, 2016·Environmental Science and Pollution Research International·Ivy Shiue
Jul 4, 2015·Environmental Toxicology and Chemistry·Jaime Rodríguez-EstivalJudit E G Smits
Jan 25, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jeanette NiestroyPeter H Roos
Mar 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abir ChahinYann Guiavarc'h
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
Sep 3, 2008·Analytical and Bioanalytical Chemistry·Christina U Köhler, Peter H Roos
Mar 24, 2020·Ecotoxicology and Environmental Safety·Jiang LiCheng Xiao

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