PMID: 15240722Jul 9, 2004Paper

Differential induction of IL-1beta and TNF by CD40 ligand or cellular contact with stimulated T cells depends on the maturation stage of human monocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
D BurgerJean-Michel Dayer

Abstract

Cellular contact with stimulated T cells potently induces cytokine production in monocytes, a mechanism that is likely to be relevant to chronic inflammation. Although the identity of surface molecules involved in this process remains elusive, CD40 and its ligand, CD40L, are thought to be implicated, considering that they are expressed at the inflammatory site. To ascertain the involvement of CD40L, we compared the activation of three different types of human monocytic cells, i.e., freshly isolated monocytes, monocytes primed with IFN-gamma (IFN-gamma-macrophages), and THP-1 cells. These cells were activated by either membranes isolated from stimulated T cells (HUT-78 or T lymphocytes) to mimic cellular contact, soluble extracts from isolated membranes, or CD40L trimer (CD40LT). The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only. Similar results were obtained with soluble extracts of T cell membranes, demonstrating that the difference between membranes and CD40LT was not due to the particulate form of membranes. CD40LT induced neither transcript nor protein of cytokines in monocytes, whereas in ...Continue Reading

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Citations

Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvio DaneseClaudio Fiocchi
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas MolnarfiDanielle Burger
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela RossolUlf Wagner
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle BurgerPatrice H Lalive
May 4, 2011·World Journal of Biological Chemistry·Wen-Qi LaiBernard P Leung
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·James O EarlyAnnie M Curtis
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Jing YangAkihito Yokoyama
Jan 1, 2021·Frontiers in Oncology·Jane KooAlisa B Lee-Sherick

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