Abstract
Cellular contact with stimulated T cells potently induces cytokine production in monocytes, a mechanism that is likely to be relevant to chronic inflammation. Although the identity of surface molecules involved in this process remains elusive, CD40 and its ligand, CD40L, are thought to be implicated, considering that they are expressed at the inflammatory site. To ascertain the involvement of CD40L, we compared the activation of three different types of human monocytic cells, i.e., freshly isolated monocytes, monocytes primed with IFN-gamma (IFN-gamma-macrophages), and THP-1 cells. These cells were activated by either membranes isolated from stimulated T cells (HUT-78 or T lymphocytes) to mimic cellular contact, soluble extracts from isolated membranes, or CD40L trimer (CD40LT). The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only. Similar results were obtained with soluble extracts of T cell membranes, demonstrating that the difference between membranes and CD40LT was not due to the particulate form of membranes. CD40LT induced neither transcript nor protein of cytokines in monocytes, whereas in ...Continue Reading
References
Jan 15, 1991·Experientia·J Auwerx
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Dec 1, 1994·European Journal of Immunology·D H WagnerJ Suttles
Oct 1, 1994·Seminars in Immunology·W C FanslowR J Armitage
Jul 1, 1995·Immunity·S Lecoanet-HenchozC Plater-Zyberk
Jan 11, 1993·FEBS Letters·J F GauchatJ Y Bonnefoy
Aug 1, 1993·The Journal of Experimental Medicine·M R AldersonM K Spriggs
Sep 1, 1994·The Journal of Experimental Medicine·M ArmantM Sarfati
Jul 1, 1995·Immunobiology·A Eilers, T Decker
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·K GerritseE Claassen
Feb 1, 1997·Nature Medicine·I B McInnesF Y Liew
Dec 31, 1997·The Journal of Clinical Investigation·K P MacDonaldR Thomas
Aug 4, 1998·The American Journal of Physiology·R L SahP H Backx
Oct 20, 1998·Arthritis and Rheumatism·D BurgerJ M Dayer
Jan 9, 1999·Molecular Immunology·S E BarbourA D Carter
Feb 20, 1999·The Journal of Biological Chemistry·J SuttlesR D Stout
Jun 29, 1999·International Immunology·E M CocciaA Battistini
Feb 26, 2000·Immunology·C RibbensC Chizzolini
Oct 12, 2000·Cytokine·A D FoeyF M Brennan
Apr 6, 2001·Blood·N HykaD Burger
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·S Ferrari-LacrazJ M Dayer
Jul 11, 2001·Cytokine·F JungoD Burger
Mar 22, 2002·Autoimmunity·M F LiuH Y Lei
Jul 12, 2002·Arthritis Research·Danielle Burger, Jean-Michel Dayer
Nov 5, 2003·Journal of Neuroimmunology·Sarah ShapiroAriel Miller
Citations
Aug 16, 2005·Journal of Korean Medical Science·Che WangTakashi Ikejima
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvio DaneseClaudio Fiocchi
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas MolnarfiDanielle Burger
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela RossolUlf Wagner
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvette BasCem Gabay
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Danielle BurgerPatrice H Lalive
May 4, 2011·World Journal of Biological Chemistry·Wen-Qi LaiBernard P Leung
Aug 6, 2010·PloS One·Rakel CarpinteroDanielle Burger
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·James O EarlyAnnie M Curtis
Jun 6, 2020·Biomedicines·Robin C SuSteven T Haller
Sep 7, 2007·Leukemia·S MeersM Delforge
Jun 15, 2006·Immunology·Hillary D LumAlexander L Rakhmilevich
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Jing YangAkihito Yokoyama
Jan 1, 2021·Frontiers in Oncology·Jane KooAlisa B Lee-Sherick
May 13, 2008·Molecular Immunology·Nicolas MolnarfiDanielle Burger