Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia

Biochemical and Biophysical Research Communications
N A EssaniH Jaeschke

Abstract

Intercellular adhesion molecule-1 (ICAM-1) and selectins (E- and P-selectin) mRNAs were determined in individual liver cell types by Northern blot analysis before and after injection of endotoxin. A constitutive expression of ICAM-1 mRNA was found in endothelial cells and Kupffer cells but not in hepatocytes. All three cell types showed upregulation of ICAM-1 mRNA after endotoxin. No constitutive selectin expression could be detected in any liver cell, but endotoxin induced massive synthesis of E- and P-selectin mRNA in endothelial cells and Kupffer cells. The differential expression of cellular adhesion molecules in the liver is consistent with the involvement of selectins in neutrophil rolling in the vasculature and ICAM-1 in transendothelial migration and adherence to parenchymal cells.

Citations

May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven B YeeRobert A Roth
Apr 20, 2014·Toxicology Letters·Benjamin L WoolbrightHartmut Jaeschke
Dec 10, 2003·The Journal of Cell Biology·Boris TchernychevBarbara C Furie
Sep 7, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Hartmut Jaeschke, Tadashi Hasegawa
Aug 30, 2005·The American Journal of Pathology·Abdel-Majid KhatibPnina Brodt
Mar 19, 2014·Acta Physiologica Hungarica·A HassounaMohamed Haidara
Jul 17, 2015·BMC Complementary and Alternative Medicine·Omolola R OyenihiOluwafemi O Oguntibeju
May 7, 2016·Journal of Hepatology·Giusi MarroneJordi Gracia-Sancho
Sep 6, 2005·The Journal of Surgical Research·Michael T SchellHobart W Harris
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A Fox-Robichaud, P Kubes
Sep 22, 1999·Gene Therapy·N GiannoukakisP Robbins
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N AhmadD L Laskin
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L BumgardnerC G Orosz
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J Maher, G J Gores
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A LawsonH Jaeschke
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ichiro OgushiJiro Fujimoto
May 1, 1996·The British Journal of Surgery·M D Menger, B Vollmar
Jul 28, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Amanda L PatrickAlison E Fox-Robichaud
Jun 6, 2013·Experimental and Therapeutic Medicine·Qian WangShufeng Bai
Nov 18, 2000·American Journal of Physiology. Cell Physiology·P LiuP Y Wong
May 12, 1998·The American Journal of Physiology·J G ChosayH Jaeschke
Aug 4, 1998·The American Journal of Physiology·C HellerbrandD A Brenner
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey R Scott, Alison E Fox-Robichaud
Sep 26, 2017·Oncology Letters·Aitor BenedictoBeatriz Arteta
Sep 26, 2020·Frontiers in Immunology·Miguel A ZarateClyde J Wright
Nov 18, 1998·Immunology Today·S H Gregory, E J Wing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.