Differential induction of NAD(P)H:quinone oxidoreductase by anti-carcinogenic organosulfides from garlic

Biochemical and Biophysical Research Communications
S V SinghJ L Orchard

Abstract

This study was undertaken to elucidate the mechanism of organ specificity and differential efficacy of garlic organosulfides (OSCs) [diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), dipropyl sulfide (DPS) and dipropyl disulfide (DPDS)] in preventing benzo(a)pyrene (BP)-induced tumorigenesis in mice. The results of the present study reveal a good correlation between chemopreventive efficacies of garlic OSCs and their inductive effects on the expression of NAD(P)H:quinone oxidoreductase (NQO), an enzyme implicated in the detoxification of activated quinone metabolites of BP. Treatment of mice with DADS and DATS, which are potent inhibitors of BP-induced forestomach tumorigenesis, resulted in a statistically significant increase (2.4- and 1.5-fold, respectively) in forestomach NQO activity. In addition, DADS and DATS were much more potent inducers of forestomach NQO activity than DAS, which is a weak inhibitor of BP-induced forestomach tumorigenesis than the former compounds. Propyl-group containing OSCs (DPS and DPDS), which do not inhibit BP-induced tumorigenesis, did not affect forestomach NQO activity. Similar to forestomach, a good correlation was also observed between effects of these OSCs against ...Continue Reading

Citations

Jun 25, 2008·The British Journal of Nutrition·Siegfried KnasmüllerKarl-Heinz Wagner
Mar 28, 2006·Journal of Natural Products·Muriel CuendetJohn M Pezzuto
Jun 2, 2009·Critical Reviews in Food Science and Nutrition·Masood Sadiq ButtJavaid Iqbal
Dec 24, 2004·Critical Reviews in Food Science and Nutrition·Farhath KhanumK R Viswanathan
Feb 21, 2006·Antioxidants & Redox Signaling·Woo-Sik JeongAh-Ng Tony Kong
Feb 24, 2001·Drug Metabolism and Drug Interactions·A M Le Bon, M H Siess
Apr 17, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N ArranzP Morales
Oct 19, 2006·Nutrition and Cancer·Hang Xiao, Kirk L Parkin
Oct 14, 2005·World Journal of Gastroenterology : WJG·Min-Wen HaYuan Yuan
Nov 24, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·A SinghY Shukla
Jan 8, 2014·Laboratory animal research·Sung-Hwan KimJong-Choon Kim
Aug 29, 2007·Acta Pharmacologica Sinica·Anna Herman-AntosiewiczShivendra V Singh
Dec 20, 2007·Journal of Cellular Biochemistry·Silvia D StanShivendra V Singh
Sep 19, 2008·Environmental and Molecular Mutagenesis·Dong XiaoShivendra V Singh
Jul 16, 2010·Cell Biochemistry and Biophysics·Ria R Ramoutar, Julia L Brumaghim
Mar 14, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Craig D FisherNathan J Cherrington
Jun 29, 2014·Human & Experimental Toxicology·I-C LeeJ-C Kim
Jul 4, 2019·Current Pharmaceutical Design·Ana PaunkovGerasimos P Sykiotis
Mar 10, 2001·The Journal of Nutrition·J A Milner
May 4, 2011·Journal of Food Science·Yue WangGang Cheng
Jan 15, 2015·Cancer Prevention Research·Holly L NicastroJohn A Milner
Jan 27, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ajay A MyneniLina Mu
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dong XiaoShivendra V Singh
Dec 8, 2005·Journal of Agricultural and Food Chemistry·Rex MundayJohn S Munday
Jan 12, 1999·Toxicology and Applied Pharmacology·D GuyonnetM Suschetet
May 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C C WuC K Lii
Apr 26, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M AliM Afzal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.