Differential Induction of Type I and III Interferons by Staphylococcus aureus.

Infection and Immunity
Adeline PeignierDane Parker

Abstract

Staphylococcus aureus is a leading cause of bacterial pneumonia, and we have shown previously that type I interferon (IFN) contributes to the pathogenesis of this disease. In this study, we screened 75 S. aureus strains for their ability to induce type I and III IFN. Both cytokine pathways were differentially stimulated by various S. aureus strains independently of their isolation sites or methicillin resistance profiles. These induction patterns persisted over time, and type I and III IFN generation differentially correlated with tumor necrosis factor alpha production. Investigation of one isolate, strain 126, showed a significant defect in type I IFN induction that persisted over several time points. The lack of induction was not due to differential phagocytosis, subcellular location, or changes in endosomal acidification. A correlation between reduced type I IFN induction levels and decreased autolysis and lysostaphin sensitivity was found between strains. Strain 126 had a decreased rate of autolysis and increased resistance to lysostaphin degradation and host cell-mediated killing. This strain displayed decreased virulence in a murine model of acute pneumonia compared to USA300 (current epidemic strain and commonly used in ...Continue Reading

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Citations

Feb 7, 2021·Trends in Microbiology·Adeline Peignier, Dane Parker
Feb 6, 2021·Frontiers in Immunology·Grace R PidwillSimon J Foster
Mar 11, 2021·PLoS Pathogens·Nathan KlopfensteinC Henrique Serezani
Jun 10, 2021·Applied and Environmental Microbiology·Santosh PaudelRitwij Kulkarni

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