Abstract
The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host-pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expressi...Continue Reading
Citations
Mar 26, 2016·Frontiers in Immunology·Khiyam HussainKaren Robinson
Oct 24, 2019·Cells·Chia-Jung KuoChih-Ho Lai
Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Apr 2, 2020·Cancers·Suneesh Kumar PachathundikandiSteffen Backert
Mar 23, 2017·World Journal of Gastroenterology : WJG·Magdalena ChmielaPaweł Stączek
Aug 22, 2018·Frontiers in Pharmacology·Chun WangAi-Ping Lu
Oct 31, 2019·Journal of Oncology·Lucía Figueroa-ProttiWarner Alpízar-Alpízar
Oct 23, 2019·Frontiers in Immunology·Hanna G GebremariamAnn-Beth Jonsson
Aug 9, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B TayeG Davey
Oct 17, 2020·Veterinary World·O K YulizalRaden Lia Kusumawati
Jan 22, 2021·Pharmacological Reports : PR·Antonio Lima BragaAna Amélia de Carvalho Melo-Cavalcante
Oct 23, 2020·Cancers·Andrea Di Pietro
Dec 7, 2017·The Journal of Contemporary Dental Practice·Kamala RajendraAnkur Vatsal
Jul 3, 2021·Antioxidants·Jose Manuel SilvanAdolfo J Martinez-Rodriguez
Aug 4, 2021·MBio·Kevin S JohnsonKaren M Ottemann