Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

Journal of Inflammation Research
Jonathan Richard WhiteKaren Robinson

Abstract

The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host-pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expressi...Continue Reading

Citations

Jan 29, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Holger Brüggemann, Munir A Al-Zeer
Mar 23, 2017·World Journal of Gastroenterology : WJG·Magdalena ChmielaPaweł Stączek
Oct 31, 2019·Journal of Oncology·Lucía Figueroa-ProttiWarner Alpízar-Alpízar
Aug 9, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B TayeG Davey
Jan 22, 2021·Pharmacological Reports : PR·Antonio Lima BragaAna Amélia de Carvalho Melo-Cavalcante
Dec 7, 2017·The Journal of Contemporary Dental Practice·Kamala RajendraAnkur Vatsal

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biopsy

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