Differential inflammatory responses in aging and disease: TNF-alpha and IL-6 as possible biomarkers

Free Radical Biology & Medicine
David de Gonzalo-CalvoAna Coto-Montes

Abstract

Oxidative stress has been reported to increase during aging and conditions of hypoxia. Although low oxygen saturation has a key role in the development of several age-related diseases, the underlying mechanisms are still unknown. We analyzed the relationship between aging and hypoxia by examining oxidative stress and inflammation-related cytokines. We collected blood samples from three volunteer experimental groups, consisting of one group of normoxic middle-aged people and two groups of individuals older than 75 years, which comprised a subgroup of normoxic subjects and another with oxyhemoglobin saturation lower than 95% (hypoxic). Our results showed a fall in antioxidant defenses in older people with hypoxia. TNF-alpha, the first element in the cytokine cascade, was significantly increased in the aged population, implying that aging is accompanied by a gradual increase in this inflammatory biomarker. IL-6 was not associated with aging, but it was highly elevated under hypoxia conditions in elderly subjects. Thus, these parameters could be used as biological markers of different inflammatory processes triggered by oxidative stress induced by a decrease in antioxidant defenses in the elderly population, with TNF-alpha as an in...Continue Reading

Citations

Nov 18, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David de Gonzalo-CalvoAna Coto-Montes
Dec 20, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David de Gonzalo-CalvoAna Coto-Montes
Oct 11, 2012·Oxidative Medicine and Cellular Longevity·Aswin Mangerich, Alexander Bürkle
Apr 27, 2012·PloS One·Jashoman BanerjeeHusam M Abu-Soud
Feb 13, 2013·Clinical & Developmental Immunology·Janaínna Grazielle Pacheco OlegárioRosana Rosa Miranda Corrêa
Nov 10, 2011·Inhalation Toxicology·Stephanie A ShoreMing Zhu
Oct 15, 2014·International Journal of Molecular Sciences·Yu LiuMan Lung Fung
Aug 1, 2013·Expert Review of Neurotherapeutics·Bianca PfaffensellerFlávio Kapczinski
Apr 24, 2014·Journal of Clinical Medicine·Lisa B Boyette, Rocky S Tuan
Mar 19, 2013·Connective Tissue Research·Yutaka YabeEiji Itoi
Dec 20, 2011·Preventive Medicine·Sahdeo PrasadBharat B Aggarwal
Jun 28, 2011·Current Opinion in Immunology·Günter Lepperdinger
May 26, 2012·European Journal of Clinical Investigation·David de Gonzalo-CalvoAna Coto-Montes
Jun 24, 2015·Revista española de geriatría y gerontología·Sergio Francisco Martínez Huenchullán, Eladio Bernabé Mancilla Solorza
Sep 30, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Alessandro de OliveiraAntônio José Natali
Oct 22, 2016·Mechanisms of Ageing and Development·Erica RuraliElisa Gambini
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kyung-Yeon ParkTae-Hwe Heo
Apr 9, 2015·Animal : an International Journal of Animal Bioscience·A Rubio-GonzálezA Coto-Montes
Apr 26, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Stephan ReitingerGünter Lepperdinger
Mar 31, 2015·Neurobiology of Aging·Rodney M RitzelLouise D McCullough
Nov 15, 2013·Autophagy·Marina García-MaciaAna Coto-Montes
Jul 24, 2012·Experimental Gerontology·Günter Lepperdinger
Oct 26, 2013·Sleep Medicine·Yun-Hsiang ChenChia-Hsiang Chen
Jun 11, 2014·Journal of Molecular Neuroscience : MN·Xiuzhe WangMarianne Schultzberg
Apr 20, 2016·Journal of Pineal Research·Beatriz de Luxán-DelgadoAna Coto-Montes
Oct 27, 2016·International Journal of Molecular Sciences·Ana Coto-MontesRussel J Reiter
Feb 16, 2013·The Australian and New Zealand Journal of Psychiatry·Benicio N FreyL Trevor Young
Apr 19, 2017·Animal : an International Journal of Animal Bioscience·Y PotesA Coto-Montes
Apr 22, 2017·The Journal of Nutritional Biochemistry·Michael J PagliassottiThomas J LaRocca
Oct 5, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bryon A TompkinsJoshua M Hare
Nov 1, 2017·Molecular Neurobiology·Adrian Rubio-GonzálezUNKNOWN Members of Research Team cROS (cellular Response to Oxidative Stress)
Feb 15, 2018·Sleep·Bharati PrasadTerri E Weaver
Aug 15, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C Milan-MattosA M Catai
Apr 3, 2016·Journal of Leukocyte Biology·Dessi LoukovDawn M E Bowdish
Jan 13, 2016·Zeitschrift für Gerontologie und Geriatrie·Gan-Zhong WeiWen-Ru Tang
Feb 19, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xianglun ZhangHongbo Zhao

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