Differential influence of family history of hypertension and premature myocardial infarction on systolic blood pressure and left ventricular mass trajectories in youth

Pediatrics
J Caroline DekkersHarold Snieder

Abstract

To examine the influence of genetic susceptibility to essential hypertension (EH) and the genetic susceptibility to premature myocardial infarction (MI) on longitudinal development of systolic blood pressure (SBP) and left ventricular mass (LVM) in youth. Individual SBP and LVM growth curves across age were created for a sample of 745 subjects (age range: 4.9-27.5 years) and a sample of 687 subjects (age range: 8.2-27.5 years), respectively. Each sample had an approximately equal proportion of African American and European American males and females, with annual assessments over a 10-year period. Family history (FH) of EH and FH of premature MI were used as measures of genetic susceptibility to EH and to premature MI, respectively. Positive FH (FH(+)) of EH and of premature MI were defined, respectively, as verified EH in 1 or both biological parents, and verified MI in any biological parent or grandparent before 55 years of age. Subjects with an FH(+) of EH had higher SBP levels and stronger increases in SBP over time than subjects with a negative FH (FH(-)) of EH. Subjects with an FH(+) of EH also showed higher LVM levels than subjects with an FH(-) of EH. In addition, the effect of an FH(+) of EH on LVM was stronger in femal...Continue Reading

References

Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A CelentanoO de Divitiis
Jan 1, 1994·American Journal of Hypertension·J M DysartW B Strong
May 1, 1994·Journal of the American College of Cardiology·R F Gillum
Mar 10, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F A TreiberH Davis
May 5, 2001·American Journal of Hypertension·B B CookG K Kapuku
Mar 5, 2002·Archives of Internal Medicine·Athanase BenetosLouis Guize
May 23, 2002·Hypertension·Caroline DekkersHarold Snieder
Dec 4, 2002·The Journal of Pediatrics·J Caroline DekkersFrank A Treiber

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Citations

Mar 28, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zhibin LiXiaoling Wang
Jul 11, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R H PodolskyH Snieder
Mar 15, 2006·Annual Review of Public Health·Ihab HajjarTheodore A Kotchen
Nov 13, 2012·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Doroteia SilvaHelena Almeida
Nov 25, 2004·Pediatric Clinics of North America·Meryl S Cohen
Mar 17, 2005·Circulation·Ivor J BenjaminUNKNOWN American Heart Association Basic Science Writing Group

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