Differential influence of haloperidol and sulpiride on dopamine receptors and peptide mRNA levels in the rat striatum and pituitary

Brain Research. Molecular Brain Research
M JaberB Bloch

Abstract

We examined the effect of chronic administration (14 days) of haloperidol (2 mg/kg/day) or sulpiride (100 mg/kg/day), on the mRNA levels of various genes in the rat striatum and pituitary by quantitative in situ and Northern blot hybridizations. In the pituitary, haloperidol and sulpiride induced similar increases of mRNAs of pro-opiomelanocortin (POMC) (+65% and +73%), prolactin (PRL) (+821% and +840%) and growth hormone (GH) (+32% and +47%), but sulpiride induced a greater increase of D2R mRNA (+125%) than haloperidol (+92%). In the striatum, sulpiride and haloperidol had different effects: sulpiride induced a higher increase than haloperidol of both preproenkephalin A (PPA) mRNA (+67% versus +47%) and D2 dopamine receptor (D2R) mRNAs (+72% versus +40%). Moreover, haloperidol and sulpiride had opposite effects on substance P (SP) mRNA. Haloperidol decreased the amount of SP mRNA by 20% while sulpiride increased it by 20%. The D1 dopamine receptor (D1R) mRNA level was not significantly modified after either treatment. Our results demonstrate that the effect of a chronic haloperidol treatment on striatal dopamine receptors and neuropeptide mRNA levels is different to that of sulpiride, whereas it is similar on pituitary hormone...Continue Reading

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Oct 1, 1992·Brain Research. Molecular Brain Research·M JaberB Bloch
Sep 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·D Healy
Jan 1, 1990·Journal of Molecular Neuroscience : MN·L K SrivastavaR K Mishra
Feb 1, 1991·Trends in Neurosciences·P G Strange
Aug 14, 1991·European Journal of Pharmacology·O CivelliH H Van Tol
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C Le MoineB Bloch
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F TangJ P Schwartz
Jan 1, 1982·General Pharmacology·S E O'Connor, R A Brown

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Citations

Jan 1, 1996·Journal of Neural Transmission·M Dziedzicka-WasylewskaK Wedzony
Mar 1, 1996·Psychopharmacology·B J Kinon, J A Lieberman
Mar 28, 1998·Neuropharmacology·U D'SouzaP R Buckland
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E Obuchowicz, J Turchan
Jan 19, 2012·Parkinson's Disease·Edward C LauterbachAntonio L Teixeira
Jan 1, 1996·Neuropharmacology·M JaberM G Caron
Jun 30, 2009·Free Radical Biology & Medicine·Anne M Galea, Andrew J Brown
Mar 5, 2003·Journal of Neurochemistry·Christian E GrossErwan Bezard
Apr 18, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edward C Lauterbach
Sep 25, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta KotWładysława A Daniel
Feb 23, 2020·Biomolecules·Ewelina ZaorskaMarcin Ufnal
Feb 11, 1998·Physiological Reviews·C MissaleM G Caron

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