Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice

Behavioral Neuroscience
Jules B Panksepp, Garet P Lahvis

Abstract

Laboratory rodents can adopt the pain or fear of nearby conspecifics. This phenotype conceptually lies within the domain of empathy, a bio-psycho-social process through which individuals come to share each other's emotion. Using a model of cue-conditioned fear, we show here that the expression of vicarious fear varies with respect to whether mice are raised socially or in solitude during adolescence. The impact of the adolescent housing environment was selective: (a) vicarious fear was more influenced than directly acquired fear, (b) "long-term" (24-h postconditioning) vicarious fear memories were stronger than "short-term" (15-min postconditioning) memories in socially reared mice whereas the opposite was true for isolate mice, and (c) females were more fearful than males. Housing differences during adolescence did not alter the general mobility of mice or their vocal response to receiving the unconditioned stimulus. Previous work with this mouse model underscored a genetic influence on vicarious fear learning, and the present study complements these findings by elucidating an interaction between the adolescent social environment and vicarious experience. Collectively, these findings are relevant to developing models of empath...Continue Reading

Citations

Feb 16, 2017·Annual Review of Animal Biosciences·Stacey J Sukoff Rizzo, Jacqueline N Crawley
Dec 14, 2017·Nature Communications·Marc T PisanskyJonathan C Gewirtz
Sep 29, 2018·Genes, Brain, and Behavior·Arie KimHee-Sup Shin
Oct 31, 2018·Genes, Brain, and Behavior·Marie H Monfils, Laura A Agee
Nov 23, 2019·Current Protocols in Neuroscience·Kacper KondrakiewiczEwelina Knapska
Mar 30, 2020·Nature Reviews. Neuroscience·Andreas OlssonBjörn Lindström
May 6, 2021·Wiley Interdisciplinary Reviews. Cognitive Science·Ana Pérez-Manrique, Antoni Gomila
Oct 7, 2020·Neuroscience and Biobehavioral Reviews·Julen Hernandez-LallementMaria Carrillo

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