Differential inhibition of stress-induced adrenocortical responses by 5-HT1A agonists and by 5-HT2 and 5-HT3 antagonists

Psychoneuroendocrinology
D SaphierJ E Welch

Abstract

The present studies were designed to determine the effects of 5-HT1A receptor agonists and 5-HT2A/2C and 5-HT3 antagonists on adrenocortical responses to a variety of stress paradigms in conscious male rats. The following stressors were examined: acoustic stress (105 dB for 2 min); foot shock (0.2 mA, five shocks over 5 min); conditioned fear (animals placed in the foot shock chamber for 5 min, 24 h after foot shock); restraint (Plexiglas restrainer for 5 min); injection of recombinant human interleukin-1 alpha (IL-1, 20 micrograms/kg, IP); injection of cocaine hydrochloride (20 mg/kg, IP). Drug treatments consisted of intracerebroventricular (ICV) or intraperitoneal (IP) injections of the 5-HT1A agonists, 8-OH-DPAT and ipsapirone (0.1 pmol, ICV), the 5-HT2A/2C antagonist, ketanserin (2 mumol/kg, IP), and the 5-HT3 antagonist, MDL-72222 (20 nmol, ICV). The plasma corticosterone (CS) responses to foot shock and restraint stress were not affected by any of the serotonergic drugs tested. The 5-HT1A agonist, 8-OH-DPAT, was able to attenuate the adrenocortical responses to acoustic stimulation, conditioned fear, IL-1 alpha, and cocaine administration, with ipsapirone also being effective in reducing the responses to acoustic stimula...Continue Reading

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Citations

Jun 1, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Donn A Simmons, Patricia A Broderick
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
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May 8, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anne-Cécile PetitEmmanuelle Corruble
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Feb 24, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hsiang-Yi TsaiYen Kuang Yang
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Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Seema Bhatnagar, Courtenay Vining
Aug 2, 2020·The Journal of Experimental Biology·Constance PierreSylvie Rétaux

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