Differential inhibition of type I interferon induction by arenavirus nucleoproteins

Journal of Virology
Luis Martínez-SobridoJuan C de la Torre

Abstract

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.

References

Jan 1, 1986·Medical Microbiology and Immunology·R M ZinkernagelL Stitz
Jul 3, 1999·The Pediatric Infectious Disease Journal·L L Barton, M B Mets
Sep 27, 2000·American Journal of Ophthalmology·M B MetsT G Ksiazek
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C F BaslerP Palese
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L L Barton, M B Mets
May 4, 2002·Current Topics in Microbiology and Immunology·C J Peters
May 4, 2002·Current Topics in Microbiology and Immunology·J B McCormick, S P Fisher-Hoch
May 4, 2002·Current Topics in Microbiology and Immunology·R M Zinkernagel
May 4, 2002·Current Topics in Microbiology and Immunology·M B A Oldstone
Dec 26, 2002·American Journal of Obstetrics and Gynecology·Leslie L BartonCynthia L Beauchamp
Jun 28, 2003·Journal of Virology·Christopher F BaslerAdolfo García-Sastre
Dec 4, 2004·Nature Medicine·Thomas W Geisbert, Peter B Jahrling
Jun 16, 2005·Current Opinion in Immunology·Mike Bray
Jun 16, 2005·Journal of Virology·Jorge L Muñoz-JordánAdolfo García-Sastre
Feb 16, 2006·Virology·Ana B Sánchez, Juan C de la Torre
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lukas FlatzDaniel D Pinschewer
May 26, 2006·The New England Journal of Medicine·C J Peters
May 26, 2006·The New England Journal of Medicine·Staci A FischerUNKNOWN LCMV in Transplant Recipients Investigation Team
Apr 7, 2007·The Journal of General Virology·Stefanie MüllerStephan Günther
Jul 1, 1963·The American Journal of Tropical Medicine and Hygiene·W G DownsA H Greenhall

❮ Previous
Next ❯

Citations

May 29, 2008·Archives of Virology·Shuiyun LanYuying Liang
Apr 5, 2013·Archives of Virology·Frank LennartzWolfgang Garten
Nov 19, 2010·Nature·Xiaoxuan QiChangjiang Dong
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kathryn M HastieErica Ollmann Saphire
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kathryn M HastieErica Ollmann Saphire
Mar 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yu GuoZihe Rao
May 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mickaël BouvetEtienne Decroly
Apr 26, 2013·The Journal of Biological Chemistry·Xue JiangChangjiang Dong
Aug 6, 2010·Journal of Virology·Sheli R RadoshitzkySina Bavari
Apr 26, 2012·Journal of Virology·Christelle PythoudStefan Kunz
Apr 2, 2010·Journal of Virology·Kristine M RoseSusan R Weiss
Oct 12, 2010·Journal of Virology·Olga A KolokoltsovaSlobodan Paessler
Sep 2, 2011·Journal of Virology·Christian D CuevasSusan R Ross
Apr 26, 2012·Journal of Virology·Melissa W HayesIgor S Lukashevich
May 25, 2012·Journal of Virology·W W Shanaka I RodrigoLuis Martínez-Sobrido
Jun 16, 2011·Virology Journal·Steven B BradfuteSina Bavari
May 17, 2011·PLoS Neglected Tropical Diseases·Allison GrosethStephan Becker
May 26, 2012·PLoS Neglected Tropical Diseases·Cheng HuangSlobodan Paessler
Sep 1, 2012·PloS One·Kathryn M HastieErica Ollmann Saphire
Nov 22, 2012·Viruses·Florencia N LineroElsa B Damonte
Dec 4, 2012·Viruses·Nadezhda E Yun, David H Walker
Dec 4, 2012·Viruses·Melissa Hayes, Maria Salvato
Dec 4, 2012·Viruses·Ashley GrantSlobodan Paessler
Dec 4, 2012·Viruses·Igor S Lukashevich
Dec 4, 2012·Viruses·Marion RussierSylvain Baize
Dec 4, 2012·Viruses·Sarah Katharina FehlingThomas Strecker
Jan 25, 2013·Viruses·Magali E Droniou-Bonzom, Paula M Cannon
Feb 26, 2013·Viruses·Svenja WolffAllison Groseth
Nov 30, 2011·Future Microbiology·Brian B Gowen, Mike Bray
Jul 10, 2010·Journal of Biomedicine & Biotechnology·Gavin C Bowick, Alan D T Barrett
Nov 6, 2012·Annual Review of Pathology·Slobodan Paessler, David H Walker
Dec 22, 2010·Expert Review of Anti-infective Therapy·Marie-Laurence Moraz, Stefan Kunz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.