PMID: 8964596Jan 1, 1996Paper

Differential interleukin (IL)-10 and IL-13 gene expression in vivo in salivary glands and peripheral blood mononuclear cells from patients with primary Sjögren's syndrome

Immunology Letters
G M VillarrealL Llorente

Abstract

Primary Sjögren's syndrome (PSS) is an autoimmune inflammatory disorder characterized by lymphocytic infiltration of exocrine glands, B cell hyperactivity and autoantibody production. The aim of this study was to determine the presence of IL-10 and IL-13 in this disease. We studied the IL-10 and IL-13 gene expression in vivo by peripheral blood mononuclear cells and minor salivary glands from PSS patients. We found a high expression of the IL-10 gene and its product by their peripheral blood mononuclear cells (PBMC) as well as by their salivary glands. Peripheral blood B cells and monocytes were responsible for 89% of total IL-10 secretion. IL-13 gene expression was not observed in PBMNC from either PSS patients or healthy controls, and was confined to PSS salivary glands. Our results suggest that IL-10 and IL-13 contribute to the pathogenesis of PSS and might explain the B cell abnormalities and the development of lymphoma observed in this autoimmune disease.

Citations

Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I LalaniA R Ahmed
Jun 18, 2002·Clinical and Experimental Immunology·D I MitsiasG Thyphronitis
Sep 17, 2005·Annals of the Rheumatic Diseases·M PertovaaraM Hurme
Jan 24, 2014·Mediators of Inflammation·L Contreras-RuizS Masli
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·D M EssayanS K Huang
Feb 17, 2019·Rheumatology·Julie MielleJacques-Olivier Pers
Jun 20, 2019·Proceedings of the National Academy of Sciences of the United States of America·Saba NayarFrancesca Barone
Jan 15, 2008·Scandinavian Journal of Rheumatology·H L RamosJ Alcocer-Varela

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