Differential kinetics of [123I]beta-CIT binding to dopamine and serotonin transporters

European Journal of Nuclear Medicine
M FujitaT Nishimura

Abstract

Iodine-123-labelled 3beta-(4-iodophenyl)tropane-2beta-carboxylic acid ([123I]beta-CIT) labels both the dopamine transporter (DAT) and the serotonin transporter (5-HTT) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. However, the differential kinetics of beta-CIT binding to DAT and 5-HTT has not been clarified fully. In this study we examined time-activity curves of [123I]beta-CIT in individual regions in the rat brain. Using cerebellum as the reference region, k3 and k4 values were estimated by a two-compartment kinetic analysis. In the striatum, the kinetics was slowest among all brain areas. In this area specific binding reached its peak 4 h after the injection. In the hypothalamus, specific binding reached its peak 1 h after the injection and its amount did not change until 4 h after the injection. In the occipital cortex, the binding and washout of the ligand were fastest among all brain regions. Estimated k3 values were 0.040+/-0.003 in the striatum, 0.019+/-0.002 in the hypothalamus and 0.082+/-0.011 in the occipital cortex (min-1, mean +/-SD). Estimated k4 values were 0.0034+/-0.0005 in the striatum, 0.0071+/-0.0009 in the hypothalamus and 0.083+/-0.013 in the occipi...Continue Reading

References

Mar 7, 1977·European Journal of Pharmacology·E FriedmanS Gershon
Feb 1, 1992·Neuropharmacology·O InoueT Suzuki
Jul 1, 1992·Journal of Pharmacological and Toxicological Methods·H T ChenD Goldman
Oct 25, 1991·Science·B J HoffmanM J Brownstein
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J FrostH N Wagner
Jan 1, 1989·Synapse·J S FowlerS J Gatley
Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D F WongH N Wagner
Oct 1, 1984·Biochemical Pharmacology·W J KinnierL Y Norrell
Feb 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·E K PerryR H Perry
Apr 1, 1995·European Journal of Nuclear Medicine·J T KuikkaP Hakola
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
Jan 1, 1993·Journal of Neural Transmission. General Section·T BrückeI Podreka
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS Wang

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Citations

Jul 27, 2001·Nuclear Medicine Communications·R BuchertM Clausen
Oct 2, 2012·EJNMMI Research·Miia PitkonenKim Bergström
Oct 11, 2005·Psychiatry Research·Swen HesseKatarina Stengler-Wenzke
Jul 17, 2013·Nuclear Medicine and Biology·Laetitia LemoineHank F Kung
Oct 19, 2006·Nuclear Medicine and Biology·Kathelijne PeremansKurt Audenaert
Jul 14, 1998·Synapse·K A BergströmJ Tiihonen
Jan 6, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D M SempleE C Johnstone
Dec 18, 2008·Expert Review of Neurotherapeutics·Angelo Antonini, Ioannis U Isaias

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