Differential lectin-bindings in normal and precancerous epithelium and squamous cell carcinoma of the oral mucosa.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Takashi Saku, H Okabe

Abstract

In order to establish a useful and objective marker of malignancy of oral mucosa, the binding sites for Ulex europaeus agglutinin I (UEA-I). Bandeiraea simplicifolia agglutinin I (BSA-I) and peanut agglutinin (PNA) were comparatively examined in the surgical materials from the normal, dysplastic and cancerous epithelium of the oral mucosa by a novel lectin-antilectin immunoperoxidase method. Based on the staining patterns of the normal keratinized epithelium, UEA-I was regarded as the marker for the prickle cells, BSA-I for the cells in the upper prickle to the horny layers, and PNA for those in the basal layer. As the degree of dysplasia advanced, all layers of epithelium came to react with UEA-I and PNA, whereas the BSA-I binding was negative. Positive reactions for UEA-I and PNA were seen in most carcinoma cells other than the keratinizing foci stained by BSA-I. The results indicate that a UEA-I-positive reaction in the basal cells, a PNA-positive in the prickle cells and loss of receptor for BSA-I occur in the course of malignant transformation of oral mucosa, and that these lectins may be regarded as useful markers of oral epithelial cytoplasmic differentiation.

References

Jan 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·D I GeorgeR L Miller
Oct 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·I R KramerL H Sobin
Nov 1, 1979·The Journal of Investigative Dermatology·P Holmstrup, E Dabelsteen
Jan 15, 1978·Archives of Biochemistry and Biophysics·M E PereiraE A Kabat
Sep 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E DabelsteenJ Reibel
Mar 1, 1987·Oral Surgery, Oral Medicine, and Oral Pathology·A H ShabanaI R Kramer
Jan 1, 1986·Differentiation; Research in Biological Diversity·S S PrimeC Scully
Nov 1, 1980·Journal of Dental Research·D I GeorgeD E Lopatin
Dec 1, 1981·Scandinavian Journal of Dental Research·P Vedtofte, M E Matthiessen
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·T LöningM vom Dahl
Jan 1, 1984·Differentiation; Research in Biological Diversity·P VedtofteW W Young
Jan 1, 1984·Cell and Tissue Research·J ReibelI C Mackenzie
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·K H HyunM Mori
May 1, 1983·The Histochemical Journal·B R Rittman, I C Mackenzie
Feb 1, 1983·Journal of Oral Pathology·A Thomopoulou-DoukoudakisM W Hill
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R K BrabecI J Goldstein
Jan 1, 1982·Archives of Oral Biology·B R RittmanG A Rittman
Jul 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M WatanabeK Ugai

❮ Previous
Next ❯

Citations

Nov 1, 1994·The Histochemical Journal·Y MizukawaH Hirano
Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·S KannanM K Nair
Apr 2, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Satoshi MaruyamaTakashi Saku
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T SakuY Yeh
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M BryneE Dabelsteen
Sep 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E DabelsteenU Mandel
Jul 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C Scully, A Burkhardt
Jan 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T NishikawaA Tanaka
Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M TabataI Maruyama
Aug 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y K Chen, L M Lin
Jul 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M TabataI Maruyama
Jul 1, 1995·Journal of Periodontal Research·Y AbeI Kato
Jul 27, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Kamarthi NagarajuL Ashok
Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M Bryne
Jun 11, 2014·Translational Oncology·John BaetenDeepak Kademani
May 31, 2013·Clinical Orthopaedics and Related Research·Jacob T MunroClive P Duncan
Jun 17, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D TsambaosG Adamopoulos
Oct 1, 1991·The Journal of Investigative Dermatology·U MandelE Dabelsteen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.