Differential levels of mRNA transcripts encoding immunologic mediators in mammary gland secretions from dairy cows with subclinical environmental Streptococci infections

Veterinary Immunology and Immunopathology
Daniela R BrunoJeffrey L Stott

Abstract

Dry-off, and the period around parturition, are associated with increased susceptibility to intramammary infections in dairy cows. The immunological profiles of mammary gland secretions during these periods are not well described. The objective of the present study was to better characterize association(s) between chronic subclinical Environmental Streptococci infections at dry-off and relative levels of mRNA transcripts encoding multiple immunologic mediators present in cells derived from mammary gland secretions at dry-off and continuing through parturition. The chronic subclinical bacterial infections in the present study were characterized by multiple isolations of Streptococcus species and elevated SSC for a minimum of three weeks prior to dry-off. The majority of differences between principal and control quarters were identified at dry-off. Transcript levels of IL-17, IL2Rα and iNOS were increased while pro-inflammatory cytokine IL-6, and the regulatory cytokine IL-10, were reduced. Following antibiotic treatment of mammary glands, IL-17 transcripts remained elevated over the course of the study, indicative of a persistent insult. IL-4 transcript levels were modestly elevated at 7 days following dry-off and significantly ...Continue Reading

References

Sep 1, 1996·Veterinary Immunology and Immunopathology·G L MasonP N Bochsler
May 11, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A M Alluwaimi, J S Cullor
Apr 2, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A M AlluwaimiJ S Cullor
Jan 31, 2004·American Journal of Reproductive Immunology : AJRI·Ken-ichi AsaiKatsuo Kumagai
Mar 10, 2004·Reproduction, Nutrition, Development·Pascal Rainard, Céline Riollet
May 13, 2004·Clinical and Diagnostic Laboratory Immunology·Douglas D BannermanPascal Rainard
Jul 28, 2004·Research in Veterinary Science·Ahmed M Alluwaimi
Oct 9, 2004·The Veterinary Clinics of North America. Food Animal Practice·Andrew J Bradley, Martin J Green
Jun 23, 2005·Veterinary Immunology and Immunopathology·Douglas D BannermanJayne C Hope
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Céline RiolletPascal Rainard
Jul 31, 2007·Veterinary Immunology and Immunopathology·Wenjing Tao, Bonnie Mallard
Aug 31, 2007·Molecular Immunology·Hichem LahouassaCéline Riollet
Jun 24, 2008·Developmental and Comparative Immunology·Tatjana SittJeffrey L Stott
Oct 25, 2008·Nature Reviews. Immunology·Jay K KollsYvonne R Chan
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards

❮ Previous
Next ❯

Citations

Aug 14, 2012·Veterinary Immunology and Immunopathology·M C HellerR M Tsolis
Apr 23, 2016·PloS One·Pascal RainardFlorence B Gilbert
Oct 8, 2018·Journal of Dairy Science·Sanjeewa D RanathungaKevin J Herrick
Dec 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adeline PorcheriePascal Rainard
Oct 17, 2020·Veterinary Research·Pascal RainardGilles Foucras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.