Abstract
Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In the present study, we analyzed NfL levels in the CSF of 535 participants of the SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We evaluated the differences in CSF NfL accross groups and its association with other CSF biomarkers and with cognitive scales. All neurogenerative diseases showed increased levels of CSF NfL, with the highest levels in patients with ALS, FTD, CBS and PSP. Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. These results have implications for the use of NfL as a marker in neurodegenerative diseases.
References
Nov 1, 1996·Journal of Neurochemistry·L E RosengrenC Wikkelsø
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Sep 23, 2003·Brain Research·Niklas NorgrenTorgny Stigbrand
Aug 25, 2004·Journal of Internal Medicine·B WinbladR C Petersen
Mar 7, 2007·Molecular Psychiatry·M BiblJ Wiltfang
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Aug 29, 2012·Archives of Neurology·Sara HallOskar Hansson
Nov 21, 2013·Journal of Alzheimer's Disease : JAD·Daniel AlcoleaJosé L Molinuevo
May 14, 2014·Journal of Alzheimer's Disease : JAD·Daniel AlcoleaAlberto Lleó
Oct 24, 2014·Neurology·Tobias SkillbäckHenrik Zetterberg
May 3, 2015·Neurology·Ching-Hua LuAndrea Malaspina
Jul 3, 2015·Brain : a Journal of Neurology·Tobias SkillbäckHenrik Zetterberg
Jul 17, 2015·Neurology·Daniel AlcoleaAlberto Lleó
Oct 21, 2015·Journal of Neurochemistry·Aiko IshikiKatsutoshi Furukawa
Jan 20, 2016·Annals of Clinical and Translational Neurology·Shorena JanelidzeOskar Hansson
Apr 14, 2016·Lancet Neurology·Bob OlssonHenrik Zetterberg
May 18, 2016·Journal of Neurochemistry·Patrick OecklMarkus Otto
Mar 7, 2017·JAMA Neurology·Alessandra GaianiGianni Sorarù
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Dilman SadiqZuzana Walker
May 4, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·María Carmona-IraguiJuan Fortea
May 21, 2017·Journal of Alzheimer's Disease : JAD·Isabel SalaAlberto Lleó
Jun 9, 2017·Neurology·Ian G McKeithKenji Kosaka
Jun 9, 2017·Neurology·Daniel AlcoleaAlberto Lleó
Jun 21, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Tobias SkillbäckHenrik Zetterberg
Apr 18, 2018·Annals of Neurology·Daphné Génier MarchandJean-François Gagnon
Apr 26, 2018·Psychological Medicine·Alan J ThomasJohn T O'Brien
Aug 18, 2018·Journal of Neurology·Antonio ScarafinoIsabella Laura Simone
Sep 3, 2018·Lancet Neurology·Juan ForteaAlberto Lleó
Oct 7, 2018·Neurology·Ignacio Illán-GalaAlberto Lleó
Oct 16, 2018·Journal of Alzheimer's Disease : JAD·Samir Abu-RumeilehPiero Parchi
Dec 7, 2018·JAMA Neurology·Bob OlssonKaj Blennow
May 28, 2019·Scientific Reports·Estrella Morenas-RodríguezAlberto Lleó
Jun 18, 2019·JAMA Neurology·Claire BridelEdward J Wild
Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel AlcoleaAlberto Lleó
Citations
Sep 3, 2020·Biomedicines·André HussHayrettin Tumani
Dec 1, 2020·Journal of Alzheimer's Disease : JAD·Lin SunShifu Xiao
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Apr 24, 2021·Frontiers in Neuroscience·Marie DregerJulian Grosskreutz
May 15, 2021·Scientific Reports·Constance DelabyM Paccalin
Jun 10, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Daniel AlcoleaAlberto Lleó
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Andrea PilottoAlessandro Padovani
Jul 9, 2021·Frontiers in Neuroscience·Federico VerdeVincenzo Silani
Jul 27, 2021·Annals of Neurology·Victor MontalUNKNOWN Down Alzheimer Barcelona Neuroimaging Initiative
Aug 18, 2021·Neurobiology of Aging·Bryant LimGeir Bråthen
Aug 28, 2021·Journal of Clinical Medicine·Laia Montoliu-GayaNicholas James Ashton
Dec 3, 2021·Current Opinion in Psychiatry·Nikolaj TravicaWolfgang Marx
Dec 8, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Giacomo SferruzzaNilo Riva
Jan 19, 2022·Journal of Neural Transmission·Martin FayolleConstance Delaby