Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders.

Scientific Reports
C DelabyA Lleó

Abstract

Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In the present study, we analyzed NfL levels in the CSF of 535 participants of the SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We evaluated the differences in CSF NfL accross groups and its association with other CSF biomarkers and with cognitive scales. All neurogenerative diseases showed increased levels of CSF NfL, with the highest levels in patients with ALS, FTD, CBS and PSP. Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. These results have implications for the use of NfL as a marker in neurodegenerative diseases.

References

Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Sep 23, 2003·Brain Research·Niklas NorgrenTorgny Stigbrand
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
May 14, 2014·Journal of Alzheimer's Disease : JAD·Daniel AlcoleaAlberto Lleó
Jul 3, 2015·Brain : a Journal of Neurology·Tobias SkillbäckHenrik Zetterberg
Jan 20, 2016·Annals of Clinical and Translational Neurology·Shorena JanelidzeOskar Hansson
May 18, 2016·Journal of Neurochemistry·Patrick OecklMarkus Otto
May 4, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·María Carmona-IraguiJuan Fortea
Jun 21, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Tobias SkillbäckHenrik Zetterberg
Apr 18, 2018·Annals of Neurology·Daphné Génier MarchandJean-François Gagnon
Apr 26, 2018·Psychological Medicine·Alan J ThomasJohn T O'Brien
Aug 18, 2018·Journal of Neurology·Antonio ScarafinoIsabella Laura Simone
Oct 7, 2018·Neurology·Ignacio Illán-GalaAlberto Lleó
Oct 16, 2018·Journal of Alzheimer's Disease : JAD·Samir Abu-RumeilehPiero Parchi
May 28, 2019·Scientific Reports·Estrella Morenas-RodríguezAlberto Lleó
Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Daniel AlcoleaAlberto Lleó

❮ Previous
Next ❯

Citations

Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Jun 10, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Daniel AlcoleaAlberto Lleó
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Andrea PilottoAlessandro Padovani
Jul 9, 2021·Frontiers in Neuroscience·Federico VerdeVincenzo Silani
Jul 27, 2021·Annals of Neurology·Victor MontalUNKNOWN Down Alzheimer Barcelona Neuroimaging Initiative
Aug 28, 2021·Journal of Clinical Medicine·Laia Montoliu-GayaNicholas James Ashton
Dec 3, 2021·Current Opinion in Psychiatry·Nikolaj TravicaWolfgang Marx
Dec 8, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Giacomo SferruzzaNilo Riva

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
genotyping

Software Mentioned

MEDCALC

Related Concepts

Related Feeds

Alzheimer's Disease: Early Markers

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive and behavioral decline. Targeting markers in the earliest stages of the disease may mitigate the progression of AD. This feed focuses on early diagnosis and markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.