Differential localization of MT1-MMP in human prostate cancer tissue: role of IGF-1R in MT1-MMP expression

The Prostate
Isis C SrokaG Tim Bowden

Abstract

MT1-MMP is a metalloproteinase involved in prostate cancer metastasis. The IGF-1R is a tyrosine kinase receptor involved with tumor progression and metastasis. The purpose of this investigation was to examine MT1-MMP and IGF-1R expression and localization in prostate cancer tissues and explore the role of IGF-1R in regulating MT1-MMP in prostate cancer cell lines. Immunohistochemistry was utilized to study MT1-MMP and IGF-1R expression in human prostate tissues. IGF-1R regulation of MT1-MMP expression was determined by gene promoter analysis, quantitative RT-PCR and Western blot analysis following pharmacological inhibition of the receptor in PC-3N cells and treatment of LNCaP cells with androgen and IGF-1. MT1-MMP expression was high in the apical regions of the luminal cells in PIN and prostate cancer and less intense in the basalateral regions of benign tissues. IGF-1R was expressed primarily in the basal cells of normal glands and highly expressed in prostate cancer. Inhibition of IGF-1R in PC-3N cells decreased MT1-MMP expression and treatment of LNCaP cells with a synthetic androgen and IGF-1 increased MT1-MMP expression. These data demonstrate that MT1-MMP is highly expressed in the apical cytoplasmic regions of the lumi...Continue Reading

References

Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·P BurfeindJ Ilan
Jan 1, 1996·Enzyme & Protein·M L CorcoranW G Stetler-Stevenson
Nov 1, 1995·Pathology, Research and Practice·R MontironiG Biagini
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study on Aging
May 22, 2001·The Journal of Biological Chemistry·T L DavisA E Cress
May 4, 2002·Neoplasia : an International Journal for Oncology Research·Monika SchmelzRaymond B Nagle
Sep 5, 2002·Nature Reviews. Cancer·Christopher Mark Overall, Carlos López-Otín
Jun 6, 2003·Cancer Metastasis Reviews·Takayuki Shiomi, Yasunori Okada
Dec 12, 2003·Drug News & Perspectives·Gaetano Romano
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D ZhangP Brodt
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pär StattinRudolf Kaaks
Nov 2, 2004·Urological Research·Giuseppe MorgiaMaria Clorinda Mazzarino
Mar 9, 2005·Cancer Research·Giuseppe PandiniAntonino Belfiore
Mar 23, 2005·Biochimie·N E Sounni, A Noel
Apr 12, 2005·Cancer Science·Hiroshi SatoHisashi Miyamori
May 28, 2005·Journal of Cellular Physiology·Yoshifumi Itoh, Motoharu Seiki
Jun 16, 2005·British Journal of Cancer·O LarssonL Girnita
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Elisabeth L BairGeorge Timothy Bowden
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ada GirnitaLeonard Girnita
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 28, 2006·Journal of Cellular Biochemistry·Jennifer D WuStephen R Plymate
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
May 9, 2006·Cancer Metastasis Reviews·Alex Y Strongin
Jul 13, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Hirotaka SatoYukie Takimoto
Oct 20, 2006·IUBMB Life·Yoshifumi Itoh
Mar 10, 2007·Journal of Cellular Physiology·Risto KajanneSirpa Leppä
Mar 14, 2007·Urologic Oncology·Charles J RyanIra D Goldfine
Mar 22, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S MaorH Werner

❮ Previous
Next ❯

Citations

Mar 23, 2012·Journal of Carcinogenesis·Subhamoy DasguptaJamboor K Vishwanatha
May 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yongmei WangDaniel D Bikle
Apr 4, 2021·International Journal of Molecular Sciences·Marley J Binder, Alister C Ward

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemical and Biophysical Research Communications
L RosengrenOlle Larsson
Proceedings of the National Academy of Sciences of the United States of America
Liyin Zhu, Jeffrey W Pollard
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Tanja NussbaumKai Breuhahn
© 2021 Meta ULC. All rights reserved