PMID: 9555065May 16, 1998Paper

Differential localization of the mRNAs for the pertussis toxin insensitive G-protein alpha sub-units Gq, G11, and Gz in the rat brain, and regulation of their expression after striatal deafferentation

Brain Research. Molecular Brain Research
I K FribergD G Standaert

Abstract

The corticostriatal pathway is among the largest glutamatergic pathways in the brain, and of particular interest to the study of glutamatergic transmission. The metabotropic glutamate receptors (mGluRs) couple the actions of glutamate to intracellular second messenger systems through G-proteins. The most prominent of the mGluRs present in the target of this pathway, the striatum, is mGluR5. The identity of the G-proteins mediating the actions of mGluR5 are unknown, but the receptor is linked to stimulation of phosphoinositide (PI) turnover and largely resistant to the effects of pertussis toxin, which inhibits some G-proteins. We used in situ hybridization to examine the expression and regulation of three pertussis toxin insensitive G-protein alpha sub-units: Gq, G11, and Gz. We found that these mRNAs are differentially distributed in the rat brain, but all three are expressed by striatal neurons. After glutamatergic deafferentation of the striatum by decortication, there is a modest upregulation of G11 mRNA, while expression of Gq and Gz are unchanged. Following dopaminergic deafferentation, expression of Gq, G11, and Gz are not altered, although expression of the pertussis-sensitive sub-unit Go is increased. Our data suggests...Continue Reading

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Citations

Dec 4, 2003·The Journal of Comparative Neurology·Scott A Oakman, James H Meador-Woodruff
Sep 9, 2006·CNS Drug Reviews·Paul M Lea, Alan I Faden
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Jun 21, 2006·Synapse·Philip SeemanTomiki Sumiyoshi
Jul 1, 2014·Biochemical and Biophysical Research Communications·Noufissa KabliSusan R George
Apr 30, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jeffery N TalbotL Charles Murrin

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