Differential loss of fat and lean mass in the morbidly obese after bariatric surgery

Metabolic Syndrome and Related Disorders
Kerstyn C ZalesinPeter A McCullough

Abstract

Bariatric surgery has become a common treatment for morbid obesity. The relative changes in body tissue that comprise the substantial weight loss over time are not completely understood. We evaluated the differential rates of fat and lean tissue losses in morbidly obese patients who underwent Roux-en-Y gastric bypass surgery. Body composition was assessed using whole-body dual energy X-ray absorptiometry (DXA) performed at two timepoints in the postoperative period. Patients were stratified by the tertile of rapidity of weight loss expressed as percent reduction in body mass index per month. Thirty two patients (25 women, 7 men) with a mean age of 46.7 +/- 10.4 years and an average initial body weight of 141.4 +/- 29.4 kg experienced a 52.3 +/- 16.6 kg (36.5 +/- 5.5%) weight loss over 13.9 +/- 6.0 months. The incremental rates of lean body mass loss by tertiles were 0.3 +/- 0.6, 0.5 +/- 0.2, and 1.0 +/- 0.8 kg/month (P = 0.02), whereas the rates of fat loss were 1.2 +/- 0.9, 1.8 +/- 0.4, and 2.9 +/- 1.0 kg/month (P = 0.0001). The ratios for lean to fat loss among the respective tertiles were 1:4.0, 1:3.6, and 1:3.0. The correlation between rates of lean and fat mass loss was r = 0.37 (P = 0.04). Only three of the 32 patients (9...Continue Reading

References

Jan 1, 1993·American Journal of Surgery·L D MacLeanR A Forse
May 1, 1993·The American Journal of Clinical Nutrition·O L SvendsenC Christiansen
Apr 29, 1998·Journal of the American Dietetic Association·D C FrankenfieldW A Rowe
Jun 1, 1997·Obesity Surgery·V GahtanA S Rosemurgy
Oct 20, 1999·JAMA : the Journal of the American Medical Association·M K SerdulaG W Heath
Apr 4, 2000·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·G M KiebzakZ Y Zhang
Jun 24, 2000·Annals of the New York Academy of Sciences·C N KistorpO L Svendsen
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Steven B HeymsfieldStanley Heshka
Dec 12, 2001·Medicine and Science in Sports and Exercise·J M JakicicUNKNOWN American College of Sports Medicine
Nov 27, 2002·Journal of the American Dietetic Association·Paula TrumboUNKNOWN Food and Nutrition Board of the Institute of Medicine, The National Academies
May 14, 2003·Annals of Nutrition & Metabolism·Giuseppe SergiGiuliano Enzi
May 23, 2003·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·W H M SarisH Wyatt
Nov 18, 2003·Acta Diabetologica·B J G StraussP E O'Brien
Mar 11, 2004·JAMA : the Journal of the American Medical Association·Ali H MokdadJulie L Gerberding
Mar 31, 2004·The Journal of Nutrition·Donald K Layman, Jamie I Baum
Oct 14, 2004·JAMA : the Journal of the American Medical Association·Henry BuchwaldKaren Schoelles
Jun 11, 2005·Chest·Michael J GallagherPeter A McCullough
Oct 6, 2005·Annals of Internal Medicine·Ramachandran S VasanRalph B D'Agostino
Nov 1, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T B ChastonP E O'Brien
Jan 16, 2007·The American Journal of Cardiology·Jody A VogelPeter A McCullough

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Citations

Jun 7, 2014·Obesity Surgery·Mirko OttoTill Hasenberg
Oct 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·David L KendlerJohn Shepherd
Dec 2, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Andrew J TeichtahlFlavia M Cicuttini
Nov 4, 2015·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Gal Dubnov-RazDani Yardeni
Aug 13, 2014·European Journal of Clinical Investigation·Carolina Gutierrez-RepisoEduardo Garcia-Fuentes
May 7, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Bjoern BuehringNeil Binkley
Jul 9, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Gladys Witt StrainDympna Gallagher
Jan 26, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C BuntJ Krakoff
Feb 4, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Abigail J ColeCarrie P Earthman
Nov 23, 2012·Annals of Nutrition & Metabolism·Nobuki GatoKenji Matsumoto
Mar 16, 2011·Circulation·Paul PoirierUNKNOWN American Heart Association Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
Jan 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Diana L AlbaAnne L Schafer
Dec 15, 2015·Obesity Surgery·Jonathan S AbelsonAlfons Pomp
Feb 7, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Hope C DavisBrian Pietrosimone
Dec 10, 2015·Annals of Surgery·Noah J SwitzerShahzeer Karmali
Oct 5, 2018·JBMR Plus·Claudia Gagnon, Anne L Schafer
Apr 13, 2018·Journal of Orthopaedic Surgery and Research·Amre HamdiAbdulmalik Altaf
Jun 19, 2019·Surgical Endoscopy·Andrew R LuhrsAlfredo D Guerron
Aug 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Vicente Herrero-AguayoAura D Herrera-Martínez
Dec 21, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Paulina Ibacache-SaavedraEnrique G Artero

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Methods Mentioned

BETA
gastric bypass
X-ray
nuclear magnetic resonance

Software Mentioned

PIXImus2

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