Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq

Chemosphere
Limei SunHuili Wang

Abstract

Exposure of endocrine disrupting chemicals (EDCs) is closely related to induction of obesity, nonalcoholic fatty liver disease (NAFLD) and other lipid-metabolism diseases. Herein, we compared the effects of three EDCs exposure (triclosan, bisphenol A and fluorene-9-bisphenol) on lipid metabolism in zebrfish (Danio rerio). The differential lipid-metabolism disorders were analyzed in depth through RNA-Seq and qRT-PCR, as well as assessment of the relationship between lipid disorder and RNA methylation. Histopathological observation along with varying physiological and biochemical indexes all identified that triclosan and bisphenol A induced liver fat accumulation in acute and chronic exposure. RNA-Seq analysis showed that triclosan exposure disrupted multiple physiological processes including drug metabolism, sucrose metabolism, fat metabolism and bile secretion. The dysregulation of lipid-metabolism related genes indicated that liver steatosis in triclosan and BPA-exposed zebrafish resulted from increased fatty acid synthetase, and uptake and suppression of β-oxidation. Besides, the dysregulation of pro-inflammatory genes and endoplasmic reticulum stress showed that triclosan and bisphenol A exposure not only induced occurrence ...Continue Reading

Citations

Feb 24, 2021·Ecotoxicology and Environmental Safety·Kaihang MiYingying Zhang
Feb 23, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Emir MalovicAnumantha G Kanthasamy
Apr 3, 2021·Ecotoxicology and Environmental Safety·Huijun ZhangJuying Li
Apr 4, 2021·Aquatic Toxicology·Keng Po LaiWilliam Ka Fai Tse
Aug 22, 2021·Environmental Research·Christopher J MartyniukLorraine Chalifour
Nov 9, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Zhu ZhuYingying Zhang

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