Differential membrane targeting of the SERCA and PMCA calcium pumps: experiments with recombinant chimeras

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Danilo GueriniErnesto Carafoli

Abstract

Structural features underlying retention of the SERCA pump in intracellular compartments and the sorting of the PMCA pump to the plasma membrane are not known. The biochemical properties of the two pumps suggest that their differential localization may respond to specific functional demands. The two pumps may control Ca(2+) gradients of different magnitude and dynamic properties. For instance, it has recently become clear that the Ca(2+) gradient across the endoplasmic reticulum (ER) membrane is smaller than that across the plasma membrane. Previous experiments with chimerical constructs of the SERCA and PMCA pumps had suggested a role for the amino-terminal domain in the ER retention of the SERCA pump. Experiments aimed at narrowing down the region responsible for the retention now indicate that the first 28 amino acids of the SERCA pump may play a role in membrane localization. Results also suggest that the formation of oligomers (possibly through the first 28 amino acids) might be critical to the retention mechanism.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Oct 1, 1991·The Journal of Cell Biology·A M Swift, C E Machamer
Jan 1, 1991·Physiological Reviews·E Carafoli
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Le BivicE Rodriguez-Boulan
Jan 1, 1989·Annual Review of Cell Biology·H R Pelham
Mar 1, 1989·The Journal of Membrane Biology·M SargiacomoE Rodriguez-Boulan
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Maruyama, D H MacLennan
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D FolettiE Carafoli
Sep 1, 1993·Current Opinion in Nephrology and Hypertension·S L GluckB S Lee
Oct 25, 1996·The Journal of Biological Chemistry·M E GrimaldiJ T Penniston
Nov 20, 1997·The Journal of Biological Chemistry·D H MacLennanN M Green
Mar 28, 1998·Trends in Biochemical Sciences·J Meldolesi, T Pozzan
Oct 29, 1998·The Journal of Biological Chemistry·V CervinoD Guerini

❮ Previous
Next ❯

Citations

Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Vincenza CusimanoVincenzo Sorrentino
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Alexander D BershadskyBenjamin Geiger
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·A M EbertD M Garrity
Apr 5, 2011·Molecular Membrane Biology·Helen R WatsonJ Malcolm East
Jan 18, 2014·Biochimica Et Biophysica Acta·Lei JiangMary L Michaelis
Oct 25, 2002·The Journal of Biological Chemistry·David S ReinerFrances D Gillin
Oct 7, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hanneke OkkenhaugAlessandro Sardini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.