PMID: 1841605Dec 1, 1991Paper

Differential methylation of HMG proteins by dexamethasone in the liver of aging rats

Aging : Clinical and Experimental Research
S Prasad, M K Thakur


In vitro methylation of HMG proteins was studied in young and old rats by incubating liver slices with (methyl-14C)methionine. The level of methylation of all the four HMG proteins was relatively higher in young, as compared to old rats. Dexamethasone stimulated the methylation of HMG 2 to 12-fold, and inhibited that of other HMGs in young rats. On the other hand, it stimulated all major HMG proteins except HMG 2, which remains unchanged in old age. Such differential methylation of HMG proteins induced by dexamethasone affects the structure and function of chromatin during aging.


Aug 28, 1979·Biochemical and Biophysical Research Communications·L C BoffaV G Allfrey
Jul 1, 1977·Journal of Gerontology·G StramentinoliS Algeri
Mar 15, 1985·Biochemical and Biophysical Research Communications·M M Chaturvedi, M S Kanungo
Oct 31, 1984·Mechanisms of Ageing and Development·M K Thakur
Jul 1, 1983·Archives of Gerontology and Geriatrics·M K Thakur
Jan 1, 1982·CRC Critical Reviews in Biochemistry·I L CartwrightG C Howard

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Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Noboru TaniguchiMartin Lotz
Sep 17, 2017·Human Cell·Noboru TaniguchiMartin Lotz

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