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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Nature Genetics

Dec 1, 2009

Akiko DoiAndrew P. Feinberg

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Abstract

Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine hu...read more

Mentioned in this Paper

Inorganic phosphate
Phosphate ion
Study of Epigenetics
Familial Hypophosphatemia
Hypermethylation
Malignant Neoplasm of Large Intestine
Malignant Tumor of Colon
CpG Islands
Guanine
Specimen Type - Fibroblasts
1
801
1
Paper Details
References
  • References13
  • Citations539
  • References13
  • Citations539
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Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Nature Genetics

Dec 1, 2009

Akiko DoiAndrew P. Feinberg

PMID: 19881528

DOI: 10.1038/ng.471

Abstract

Induced pluripotent stem (iPS) cells are derived by epigenetic reprogramming, but their DNA methylation patterns have not yet been analyzed on a genome-wide scale. Here, we find substantial hypermethylation and hypomethylation of cytosine-phosphate-guanine (CpG) island shores in nine hu...read more

Mentioned in this Paper

Inorganic phosphate
Phosphate ion
Study of Epigenetics
Familial Hypophosphatemia
Hypermethylation
1
801
1
Paper Details
References
  • References13
  • Citations539
  • References13
  • Citations539
12345...

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