Abstract
The purpose of this study was to determine the arteriolar changes that occur in the microcirculation during deliberate hypotension and general anaesthesia and whether the changes depended on the drugs used to induce vasodilatation or on the degree of systemic blood pressure decrease. Changes in the vessel diameter and the velocity of red blood cells in the mesenteric arterioles of pentobarbitone-anaesthetized rats were observed using continuous biomicroscopy. Observations were made during deliberate moderate (BP 70 mmHg) or deep (BP 50 mmHg) hypotension by titration with nicardipine, prostaglandin E1 (PGE1) or trimethaphan. Then, the responses of arterioles to locally applied noradrenaline (1 microgram) were assessed. During moderate hypotension PGE1 decreased the arteriole diameter slightly (16.7 +/- 1.6 to 14.7 +/- 1.3 microns, P < 0.05), reduced the velocity of red blood cells considerably (1.98 +/- 0.2 to 1.03 +/- 0.4 mm.sec-1, P < 0.05) and increased the contractile response of arterioles to locally-applied noradrenaline. Nicardipine and trimethaphan had no effect on the microcirculation. During deep hypotension, all drugs decreased the diameter of the arterioles slightly but reduced the velocity of red blood cells conside...Continue Reading
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May 1, 2011·Journal of Biomedical Research·Guanglei WangGongjian Liu
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