Differential microfluidic sensor on printed circuit board for biological cells analysis

Electrophoresis
Dongyuan ShiZhiming Wang

Abstract

Coulter principal based resistive pulse sensor has been demonstrated as an important platform in biological cell detection and enumeration since several decades ago. Recently, the miniaturized micro-Coulter counter has attracted much attention due to its advantages in point of care diagnostics for on chip detection and enumeration of rare cells, such as circulating tumor cells. In this paper, we present a microfluidic cytometer with differential amplifier based on Coulter principle on a SU-8 coated printed circuit board substrate. The electrical current changes induced by the blockage of the microparticles in the sensing aperture are calibrated by polystyrene particles of standard size. Finally, HeLa cells are used to evaluate the performance of the proposed device for enumeration of biological samples. The proposed cytometer is built upon the cheap and widely available printed circuit board substrate and shows its great potential as personalized healthcare monitor.

References

Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Jan 31, 2008·Lab on a Chip·Yao-Nan WangDongqing Li
Jul 26, 2008·Nature Nanotechnology·Cees Dekker
Oct 30, 2009·Lab on a Chip·Nicholas WatkinsRashid Bashir
Jun 3, 2010·Nano Letters·Lorenz J SteinbockUlrich F Keyser
Nov 5, 2010·Seminars in Thrombosis and Hemostasis·Jeffrey I Zwicker
Sep 21, 2013·IEEE Transactions on Biomedical Circuits and Systems·Jinhong GuoYuejun Kang
May 23, 2014·Biomedical Microdevices·Jinhong GuoYuejun Kang

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Citations

Oct 5, 2016·Biomedical Optics Express·Chien-Shun Yan, Yao-Nan Wang
Mar 16, 2017·Lab on a Chip·Despina Moschou, Angeliki Tserepi
Jan 17, 2020·Electrophoresis·Wenhao ZhaoLijuan Dong
May 2, 2020·Electrophoresis·Jianke LuoQing Li
Jun 19, 2020·Sensors·Ferran MartínMarta Gil

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