Differential modulation by protein kinase C of progesterone-activated responses in human sperm

Biochemical and Biophysical Research Communications
C ForestaF Di Virgilio

Abstract

Progesterone exerts important effects on human spermatozoa by rapid non genomic mechanisms of action. It has been demonstrated that processes triggered by this steroid are dependent on the activation of calcium influx through the plasma membrane. Beside calcium, progesterone also induces a rapid plasma membrane depolarization that is dependent on an influx of sodium through a putative progesterone-activated channel located on the plasma membrane. In this study we show that protein-kinase C inhibition inhibits calcium influx activated by progesterone, while leaving the depolarizing effect of this steroid unchanged. These results may be explained by the existence of two progesterone receptors on human sperm plasma membrane, one responsible for calcium influx and modulated by protein-kinase C and the other selectively permeable to sodium that is not under protein-kinase C control. Alternatively, protein-kinase C inhibition might change ion selectively of a single progesterone-activated channel, thus decreasing calcium permeability, while leaving sodium permeability unchanged.

Citations

Jan 1, 1997·Annual Review of Physiology·M Wehling
Jan 31, 2012·Steroids·Alexandra WendlerMartin Wehling
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Meili ZhangPeter K T Pang
Feb 9, 2000·Frontiers in Neuroendocrinology·B M SchmidtM Wehling
Jun 12, 2016·Biochimica Et Biophysica Acta·Nofrat SchwartzBarbara D Boyan
Oct 21, 2011·Physiological Reviews·Alberto DarszonClaudia L Treviño
Aug 11, 2018·Bulletin of Mathematical Biology·Julie Simons, Lisa Fauci
Jun 1, 1995·Journal of Endocrinological Investigation·A Lenzi
Apr 30, 1999·Physiological Reviews·A DarszonF Espinosa
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R D MinshallK Hermsmeyer
Aug 25, 2005·Journal of Endocrinological Investigation·E DomaliI E Messinis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.