Differential modulation of glucocorticoid and progesterone receptor transactivation.

Molecular and Cellular Endocrinology
D SzaparyS Stoney Simons

Abstract

The determinants of the different biological activities of progesterone receptors (PRs) vs. glucocorticoid receptors (GRs), which bind to the same DNA sequences, remain poorly understood. The mechanisms by which differential expression of a common target gene can be achieved by PR and GR include unequal agonist steroid concentrations for half maximal induction (EC50) and dissimilar amounts of residual partial agonist activity for antisteroids in addition to the more common changes in total gene induction, or Vmax. Several factors are known to alter some or all of these three parameters for GR-regulated gene induction and some (i.e., the corepressors NCoR and SMRT) modulate the EC50 and partial agonist activity for GR and PR induction of the same gene in opposite directions. The current study demonstrates that other factors known to modulate GR properties (GME, GMEB-2, Ubc9, and STAMP) can also differentially interact with PRs or alter several of the above induction parameters under otherwise identical conditions. These results support the hypothesis that the modulation of EC50, partial agonist activity, and Vmax by a given factor is not limited to one receptor in a specific cell line. Furthermore, the number of factors that une...Continue Reading

Citations

Apr 9, 2010·BMC Cancer·Yuanzheng HeS Stoney Simons
Nov 15, 2008·Molecular and Cellular Endocrinology·Katharina RonacherJanet P Hapgood
Jun 28, 2008·Molecular and Cellular Endocrinology·Yunguang SunS Stoney Simons
Jul 16, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Stoney Simons
Dec 18, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Hany A Abdel-Hafiz, Kathryn B Horwitz

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