Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics

Anesthesia and Analgesia
Ken SoltDouglas E Raines

Abstract

N-Methyl-d-aspartate (NMDA) receptors have a presumed role in excitatory synaptic transmission and nociceptive pathways. Although previous studies have found that inhaled anesthetics inhibit NMDA receptor-mediated currents at clinically relevant concentrations, the use of different experimental protocols, receptor subtypes, and/or tissue sources confounds quantitative comparisons of the NMDA receptor inhibitory potencies of inhaled anesthetics. In the present study, we sought to fill this void by defining, using the two-electrode voltage-clamp technique, the extent to which diverse clinical and aromatic inhaled anesthetics inhibit the NR1/NR2B subtype of the human NMDA receptor expressed in Xenopus laevis oocytes. At 1 minimum alveolar anesthetic concentration (MAC), anesthetic compounds reversibly inhibited NMDA receptor currents by 12 +/- 6% to 74 +/- 6%. These results demonstrate that equianesthetic concentrations of inhaled anesthetics can differ considerably in the extent to which they inhibit NMDA receptors. Such differences may be useful for defining the role that this receptor plays in producing the in vivo actions of general anesthetics.

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Citations

Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
Sep 16, 2008·British Journal of Anaesthesia·R J Brosnan, T L Pham
Jun 11, 2009·British Journal of Anaesthesia·H C Hemmings
Jun 8, 2012·BMC Anesthesiology·Robert J Brosnan, Roberto Thiesen
May 24, 2008·Anesthesia and Analgesia·Aubrey YaoJoseph F Antognini
Jul 18, 2008·Anesthesia and Analgesia·Andrew JenkinsEdmond I Eger
Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Oct 22, 2008·Anesthesia and Analgesia·Takafumi HorishitaR Adron Harris
Sep 16, 2011·Anesthesia and Analgesia·Peter Gabriel PryzbylkowskiLinda Chen
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guohua ZhangZhongcong Xie
Dec 18, 2013·European Journal of Pharmacology·Andrey B PetrenkoHiroshi Baba
Feb 18, 2014·Medical Gas Research·Mike WangRichard L Applegate
Nov 12, 2014·The Journal of General Physiology·Karl F HeroldHugh C Hemmings
May 27, 2008·Experimental Neurology·Chiho KudoCenk Ayata
Aug 26, 2010·British Journal of Pharmacology·P-L Chau
Jan 13, 2015·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Frederick A ZeilerMichael West
Jan 8, 2015·Frontiers in Systems Neuroscience·Jonathan D KennyKen Solt
Nov 5, 2016·Neurotoxicology·Silvia L CruzMaría Teresa Rivera-García
Oct 19, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideto KitanoStephanie J Murphy
Sep 9, 2006·Current Opinion in Anaesthesiology·Kristin Engelhard, Christian Werner
Jul 11, 2007·Current Opinion in Anaesthesiology·Ken Solt, Stuart A Forman
Oct 26, 2007·Anesthesia and Analgesia·Elizabeth W KellyDouglas E Raines
Apr 26, 2007·Anesthesia and Analgesia·Yi ZhangJames M Sonner
Apr 2, 2015·American Journal of Therapeutics·Sang Hun KimSergio D Bergese
Nov 18, 2015·A & a Case Reports·Baiba Senbruna, Jerrold Lerman
Feb 22, 2007·Anesthesia and Analgesia·R Daniel MellonBob A Rappaport
Dec 21, 2017·Journal of Molecular Modeling·Zenaida Peralta-Inga ShieldsJane S Murray

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