Differential modulation of rat neuronal nicotinic receptor subtypes by acute application of ethanol

British Journal of Pharmacology
P J Covernton, J G Connolly

Abstract

1. We have studied the effects of acute ethanol (EtOH) exposure on the agonist responses of rat neuronal nicotinic receptors expressed in Xenopus oocytes by means of voltage clamp techniques. 2. In some cells, agonist-induced current responses with the alpha 3 beta 4 subunit combination could be either significantly potentiated or inhibited (range 25% to 237% of control response) by low ethanol concentrations (1-30 mM). At high ethanol concentrations (100-300 mM) robust potentiations were observed (range 135% to 305% of control). 3. The low EtOH concentration effects on the alpha 3 beta 4 subtype exhibited tolerance with repeated EtOH exposure. 4. In general, the alpha 3 beta 2, alpha 4-1 beta 2 and alpha 4-1 beta 4 subunit combinations were less sensitive to low concentrations of ethanol, but respectively showed potentiations of up to 178%, 226% and 154% at high EtOH concentrations. 5. The alpha 7 homomeric receptor was also relatively insensitive at low EtOH concentrations. At high EtOH concentrations, potentiations, inhibitions or no alteration of control agonist response were observed (range 88% to 141% of control). 6. We conclude that all the neuronal nicotinic receptor subunit combinations tested here can be modulated by ...Continue Reading

References

May 1, 1992·Trends in Pharmacological Sciences·H H Samson, R A Harris
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·C M de FiebreA C Collins
Oct 26, 1992·Neuroscience Letters·D BertrandM Ballivet
Jan 1, 1991·Annals of the New York Academy of Sciences·Y AracavaE X Albuquerque
Sep 23, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D C Ogden, D Colquhoun
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J BoulterJ Patrick
Jan 15, 1988·Biochemical and Biophysical Research Communications·J K PaiM M Billah
Feb 17, 1994·Nature·N P Franks, W R Lieb
May 1, 1995·Clinical and Experimental Pharmacology & Physiology·M OortgiesenH P Vijverberg
Nov 9, 1993·European Journal of Pharmacology·O BlomqvistB Söderpalm
Mar 1, 1993·Journal of Substance Abuse Treatment·L T KozlowskiC A Haertzen
Oct 18, 1996·Neuroscience Letters·K NagataT Narahashi

❮ Previous
Next ❯

Citations

Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Apr 6, 2013·Pflügers Archiv : European journal of physiology·Lynda Sharrett-FieldMark A Prendergast
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·Anna Larsson, Jörgen A Engel
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·E J PopkeM G Paule
Jul 16, 1999·Neurochemistry International·T NarahashiK Nagata
Nov 24, 1999·Neurochemistry International·R Clayton, J J Woodward
Aug 26, 1998·Drug and Alcohol Dependence·R A HarrisC F Valenzuela
Sep 19, 2002·British Journal of Pharmacology·Ambuja S BaleJohn J Woodward
Aug 2, 2002·Neuroreport·John G ConnollyMark W Head
Nov 5, 1999·Alcoholism, Clinical and Experimental Research·R A Harris
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·W MarszalecT Narahashi
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·T MoriT Narahashi
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·T NarahashiN Sato
Mar 10, 2009·Pharmacological Reviews·Alex M Dopico, David M Lovinger
Mar 12, 2008·Neurobiology of Learning and Memory·Noemi Robles, Josefa Sabriá
Nov 3, 2007·Respiratory Physiology & Neurobiology·Barbara E TaylorAnn L Wilson
Apr 10, 2007·Alcohol·Agnieszka KorkoszPrzemyslaw Bienkowski
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Barbara J BowersJeanne M Wehner
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Douglas P Dohrman And, Cindy K Reiter
Jan 9, 2007·Alcoholism, Clinical and Experimental Research·Shigeki MoriguchiToshio Narahashi
May 12, 2005·Toxicology and Applied Pharmacology·Ambuja S BaleTimothy J Shafer
Jun 14, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Agnieszka KorkoszPrzemyslaw Bienkowski
Apr 22, 2006·European Journal of Pharmacology·Agnieszka KorkoszPrzemyslaw Bienkowski
Apr 21, 2005·European Journal of Pharmacology·Agnieszka KorkoszPrzemyslaw Bienkowski
Sep 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amir H Rezvani, Edward D Levin
Jun 18, 2002·Alcoholism, Clinical and Experimental Research·Yi ZuoToshio Narahashi
Nov 26, 1999·Nature Neuroscience·T KobayashiT Kumanishi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.