Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury

American Journal of Physiology. Lung Cellular and Molecular Physiology
Koji SakamotoYoshinori Hasegawa

Abstract

Hypoxia contributes to the development of fibrosis with epithelial-mesenchymal transition (EMT) via stimulation of hypoxia-inducible factor 1α (HIF-1α) and de novo twist expression. Although hypoxemia is associated with increasing levels of surfactant protein D (SP-D) in acute lung injury (ALI), the longitudinal effects of hypoxia on SP-D expression in lung tissue injury/fibrosis have not been fully evaluated. Here, the involvement of hypoxia and SP-D modulation was evaluated in a model of bleomycin-induced lung injury. We also investigated the molecular mechanisms by which hypoxia might modulate SP-D expression in alveolar cells, by using a doxycycline (Dox)-dependent HIF-1α expression system. Tissue hypoxia and altered SP-D levels were present in bleomycin-induced fibrotic lesions. Acute hypoxia induced SP-D expression, supported by the finding that Dox-induced expression of HIF-1α increased SP-D expression. In contrast, persistent hypoxia repressed SP-D expression coupled with an EMT phenotype and twist expression. Long-term expression of HIF-1α caused SP-D repression with twist expression. Ectopic twist expression repressed SP-D expression. The longitudinal observation of hypoxia and SP-D levels in ALI in vivo was supported...Continue Reading

References

Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·Y HondaS Abe
Dec 10, 1999·American Journal of Respiratory and Critical Care Medicine·K E GreeneT R Martin
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Mar 10, 2001·The Journal of Laboratory and Clinical Medicine·N HashimotoY Hasegawa
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·R C SavaniP L Ballard
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Elisabetta A RenzoniRoland M Du Bois
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·François HuauxSem H Phan
Dec 25, 2003·American Journal of Respiratory Cell and Molecular Biology·Naozumi HashimotoYoshinori Hasegawa
May 20, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael K SamoszukEugene Mechetner
Jul 5, 2005·American Journal of Respiratory and Critical Care Medicine·John CaseyMichael F Beers
Oct 14, 2005·Proceedings of the American Thoracic Society·Manu Jain, Jacob Iasha Sznajder
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Machiko IkegamiJeffrey A Whitsett
Apr 8, 2006·American Journal of Respiratory and Critical Care Medicine·Eric B MilbrandtDerek C Angus
Jun 2, 2006·Proceedings of the American Thoracic Society·Victor J Thannickal, Jeffrey C Horowitz
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kevin K KimHarold A Chapman
Mar 30, 2007·The American Journal of Pathology·Jarmila D W van der BiltInne H M Borel Rinkes
Jul 4, 2007·Proceedings of the American Thoracic Society·Amy M PastvaKristi L Williams
Sep 1, 2007·American Journal of Respiratory and Critical Care Medicine·Argyris TzouvelekisVassilis Aidinis
Feb 26, 2008·Nature Cell Biology·Muh-Hwa YangKou-Juey Wu
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·Deepika JainMichael F Beers
Jun 9, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yasuyuki TakagiYoshinori Hasegawa
Sep 22, 2009·American Journal of Respiratory Cell and Molecular Biology·Naozumi HashimotoYoshinori Hasegawa
Oct 6, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Guofei ZhouJacob I Sznajder
Oct 24, 2009·PloS One·Veronika PozharskayaAna L Mora
Oct 28, 2009·Chest·Lorraine B WareUNKNOWN NHLBI ARDS Clinical Trials Network
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Atsuyasu SatoMachiko Ikegami
Sep 17, 2010·The New England Journal of Medicine·Arthur S Slutsky
Jan 19, 2011·American Journal of Respiratory and Critical Care Medicine·Larissa A Shimoda, Gregg L Semenza
Apr 2, 2011·American Journal of Respiratory Cell and Molecular Biology·Yoko ItoRobert J Mason
Dec 27, 2011·American Journal of Respiratory and Critical Care Medicine·Yoshinori AonoJo Rae Wright

❮ Previous
Next ❯

Citations

Apr 21, 2016·Cancer Cell International·Takashi KohnohYoshinori Hasegawa
Dec 16, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Atsushi SuzukiYoshinori Hasegawa
Dec 27, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Motohiro KimuraYoshinori Hasegawa
Sep 17, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Susanne HeroldIstván Vadász
Jan 22, 2020·Annual Review of Immunology·Sean P ColganCormac T Taylor
Jan 10, 2018·Journal of Cellular and Molecular Medicine·Xiaoxuan NingShiren Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.