Differential modulation of the auditory steady state response and inhibitory gating by chloral hydrate anesthesia

Scientific Reports
Yuchen WangLing Qin

Abstract

Auditory steady state response (ASSR) and inhibitory gating (IG) are electrophysiological examinations commonly used to evaluate the sensory and cognitive functions of the brain. In some clinic examinations and animal experiments, general anesthesia is necessary to conduct electrophysiological recordings. However, the effects of anesthesia on ASSR and IG remain unclear. For this reason, we recorded local field potentials though electrodes implanted in different brain areas of rats: the auditory cortex (AC), hippocampus (HC), amygdala (AMY), and prefrontal cortex (PFC), and compared the characteristics of ASSR and IG under anesthetized and conscious conditions. We found that ASSR signals were the strongest in the AC, and decreased sequentially in the HP, AMY, and PFC. Chloral hydrate anesthesia significantly reduced the power and phase-locking of ASSR in the AC, HP, and AMY. In contrast, the extent of IG in the AC was weakest and it increased sequentially in the HP, AMY, and PFC. Anesthesia had less effect on the extent of IG. Our results suggest that ASSR and IG may originate from different neural circuits and that IG is more resistant to general anesthesia and therefore better suited to examining the functioning of non-auditor...Continue Reading

References

Nov 1, 1992·Biological Psychiatry·G Zouridakis, N N Boutros
Jun 1, 1991·British Journal of Anaesthesia·G Plourde, J F Boylan
Nov 1, 1990·Anesthesia and Analgesia·G Plourde, T W Picton
Sep 1, 1995·Electroencephalography and Clinical Neurophysiology·O G Lins, T W Picton
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L E AdlerJ M Giffith
Dec 15, 1996·Biological Psychiatry·K A FlachR J MacGregor
May 1, 1997·British Journal of Anaesthesia·G PlourdeV Bonhomme
Jun 5, 1998·Schizophrenia Bulletin·L E AdlerR Freedman
May 16, 2001·Psychophysiology·C M Yee, P M White
Jul 13, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·N Dolu Ozesmi C
Mar 20, 2003·Biological Psychiatry·Thomas GrunwaldChristian E Elger
Jun 7, 2003·International Journal of Audiology·Terence W PictonDavid Purcell
Dec 21, 2004·Biological Psychiatry·Simone RossiStefano Passero
Jan 29, 2005·The American Journal of Psychiatry·Lawrence E AdlerMerilyne C Waldo
May 3, 2005·Brain Research·Howard C CromwellDonald J Woodward
Jul 8, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·N N BoutrosM Kurthen
Feb 13, 2007·NeuroImage·Oleg KorzyukovNashaat N Boutros
Sep 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Collette MannPradeep J Nathan
Jan 12, 2008·Psychiatry Research·Julie V PattersonWilliam E Bunney
Jun 20, 2008·Neurobiology of Aging·Christine ThomasMatthias Weisbrod
Apr 18, 2009·NeuroImage·G P KrishnanB F O'Donnell
Apr 28, 2009·Nature·Vikaas S SohalKarl Deisseroth
Sep 4, 2009·Schizophrenia Bulletin·Colleen A BrennerBrian F O'Donnell
Jul 10, 2013·Journal of Psychiatric Research·Klevest GjiniManuel E Tancer
Sep 24, 2013·Supplements to Clinical Neurophysiology·Brian F O'DonnellSandra L Morzorati
Jan 4, 2015·The International Journal of Neuropsychopharmacology·Elyse M SullivanPatricio O'Donnell
Aug 11, 2015·PloS One·Emma LeishmanSandra L Morzorati
Aug 21, 2015·Nature Reviews. Neuroscience·Daniel C Javitt, Robert A Sweet
Feb 4, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Digavalli V SivaraoMichael K Ahlijanian

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Citations

Mar 22, 2019·Stress : the International Journal on the Biology of Stress·Yuchen WangLing Qin
Jun 13, 2019·Scientific Reports·Naoki KozonoTakuma Mihara
Sep 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Yingzhuo LiLing Qin

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