Differential mononuclear leukocyte attracting chemokine production after stimulation with active and inactivated influenza A virus

Cellular Immunology
D BussfeldH Sprenger

Abstract

After influenza A virus infection of human monocytes, we found a rapid and marked release of the mononuclear cell attracting chemokines MCP-1, MIP-1 alpha, and IP-10, with corresponding gene expression patterns as determined by Northern blot analysis. In striking contrast, the expression and release of the neutrophil chemoattractant IL-8 was not inducible. To determine the underlying mechanisms responsible for the induction of this differential chemokine pattern, we stimulated monocytes with UV- and heat-inactivated (56 degrees C and 100 degrees C) influenza A virus. In comparison with fully infectious influenza A, 56 degrees C-inactivated virus induced a strong production of MCP-1, MIP-1 alpha, and IP-10, while the release of MIP-1 alpha and IP-10 was substantially lower after exposure to UV-inactivated virus. No chemokine expression was found after stimulation with 100 degrees C-inactivated influenza A virus. Our data indicate that, contingent upon the chemokine examined, the maximal induction depends on the unrestricted infectivity of the virus, the unaltered hemagglutinin molecule, or the intact viral RNA. This diversified chemokine production may enable the infected host to mount an efficient antiviral response against inf...Continue Reading

References

May 1, 1991·Cytokine·T J Schall
Apr 15, 1981·Virology·R T HuangH D Klenk

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Citations

Aug 5, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D BussfeldH Sprenger
Jun 30, 2007·Cancer Biotherapy & Radiopharmaceuticals·ShuYan YangJiGui Wang
Mar 24, 2012·Journal of Leukocyte Biology·Judith FriesenhagenDorothee Viemann
May 26, 2004·Brain, Behavior, and Immunity·Linda A Toth, Larry F Hughes
Mar 26, 2013·Molecular Immunology·Elisa CrisciMaria Montoya
Jun 22, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Michael F E RoeDiarmuid R O'Donnell
Sep 15, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·F Diaz-MitomaA Giulivi
Aug 17, 2005·FEMS Microbiology Reviews·Edward W A BrydonClive Sweet
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Matthew SchallerSteven L Kunkel
May 8, 2018·Tissue Engineering. Part a·Rudra BhowmickHeather Gappa-Fahlenkamp
Jan 11, 2007·Immunology and Cell Biology·Nicole L La GrutaPeter C Doherty
Aug 30, 2013·Expert Review of Vaccines·Nicola Principi, Susanna Esposito
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chunfeng QuGwendalyn J Randolph
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne HeroldJuergen Lohmeyer
Oct 16, 2019·Journal of Immunology Research·Prem P Lamichhane, Amali E Samarasinghe
May 9, 2000·Veterinary Microbiology·K Van Reeth

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