Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction

The EMBO Journal
Raúl MéndezJoel D Richter

Abstract

Translational activation of several dormant mRNAs in vertebrate oocytes is mediated by cytoplasmic polyadenylation, a process controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein CPEB. The translation of CPE-containing mRNAs does not occur en masse at any one time, but instead is temporally regulated. We show here that in Xenopus, partial destruction of CPEB controls the temporal translation of CPE-containing mRNAs. While some mRNAs, such as the one encoding Mos, are polyadenylated at prophase I, the polyadenylation of cyclin B1 mRNA requires the partial destruction of CPEB that occurs at metaphase I. CPEB destruction is mediated by a PEST box and Cdc2-catalyzed phosphorylation, and is essential for meiotic progression to metaphase II. CPEB destruction is also necessary for mitosis in the early embryo. These data indicate that a change in the CPEB:CPE ratio is necessary to activate mRNAs at metaphase I and drive the cells' entry into metaphase II.

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Citations

Oct 5, 2011·Cell and Tissue Research·Pavla KarabinovaAndrej Susor
Jan 16, 2009·Molecular Biotechnology·John H Doonan, Georgios Kitsios
Dec 4, 2003·Current Opinion in Cell Biology·Takeo Kishimoto
Apr 21, 2005·Seminars in Cell & Developmental Biology·Irma Sánchez, Brian David Dynlacht
Mar 22, 2003·Developmental Biology·Carlos G ReverteLaura E Hake
Jun 10, 2008·Nature Cell Biology·Carolina EliscovichRaúl Méndez
Nov 7, 2006·Nature Structural & Molecular Biology·Quiping CaoJoel D Richter
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kyung Won KimJudith Kimble
Nov 26, 2010·The Journal of Biological Chemistry·Ryoma OtaMasakane Yamashita
Jan 7, 2005·Molecular Biology of the Cell·Susana E MartínezLaura E Hake
Feb 26, 2004·Nucleic Acids Research·Nicola Minshall, Nancy Standart
Feb 13, 2008·Nucleic Acids Research·Antoine GraindorgeYann Audic
Jun 22, 2011·Cold Spring Harbor Perspectives in Biology·Joel D Richter, Paul Lasko
Mar 12, 2003·Genes & Development·Yi-Shuian HuangJoel D Richter
Jan 19, 2006·Genes & Development·Kiran Padmanabhan, Joel D Richter
Oct 4, 2006·Genes & Development·Irina GroismanJoel D Richter
Oct 17, 2007·Genes & Development·Jong Heon Kim, Joel D Richter
Oct 24, 2012·Molecular and Cellular Biology·Morris NechamaJoel D Richter
Oct 4, 2005·Molecular and Cellular Biology·Lucy J Colegrove-OteroNancy Standart
Nov 30, 2005·Molecular and Cellular Biology·Quiping CaoJoel D Richter
May 18, 2007·Annual Review of Cell and Developmental Biology·Judith Kimble, Sarah L Crittenden
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Jul 30, 2014·Annual Review of Cell and Developmental Biology·Maria IvshinaJoel D Richter
Jul 22, 2015·Biomolecules·Melanie C MacNicolAngus M MacNicol
Apr 5, 2005·Critical Reviews in Biochemistry and Molecular Biology·Lucy J Colegrove-OteroNancy Standart

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